Daily Papers

Magnetic Resonance Imaging with tagging (tMRI) has long been utilized for quantifying tissue motion and strain during deformation. However, a phenomenon known as tag fading, a gradual decrease in tag visibility over time, often complicates post-processing. The first contribution of this study is to model tag fading by considering the interplay between T_1 relaxation and the repeated application of radio frequency (RF) pulses during serial imaging sequences. This is a factor that has been overlooked in prior research on tMRI post-processing. Further, we have observed an emerging trend of utilizing raw tagged MRI within a deep learning-based (DL) registration framework for motion estimation. In this work, we evaluate and analyze the impact of commonly used image similarity objectives in training DL registrations on raw tMRI. This is then compared with the Harmonic Phase-based approach, a traditional approach which is claimed to be robust to tag fading. Our findings, derived from both simulated images and an actual phantom scan, reveal the limitations of various similarity losses in raw tMRI and emphasize caution in registration tasks where image intensity changes over time.

Accelerating Magnetic Resonance Imaging (MRI) by taking fewer measurements has the potential to reduce medical costs, minimize stress to patients and make MRI possible in applications where it is currently prohibitively slow or expensive. We introduce the fastMRI dataset, a large-scale collection of both raw MR measurements and clinical MR images, that can be used for training and evaluation of machine-learning approaches to MR image reconstruction. By introducing standardized evaluation criteria and a freely-accessible dataset, our goal is to help the community make rapid advances in the state of the art for MR image reconstruction. We also provide a self-contained introduction to MRI for machine learning researchers with no medical imaging background.

Objective: To allow efficient learning using the Recurrent Inference Machine (RIM) for image reconstruction whereas not being strictly dependent on the training data distribution so that unseen modalities and pathologies are still accurately recovered. Methods: Theoretically, the RIM learns to solve the inverse problem of accelerated-MRI reconstruction whereas being robust to variable imaging conditions. The efficiency and generalization capabilities with different training datasets were studied, as well as recurrent network units with decreasing complexity: the Gated Recurrent Unit (GRU), the Minimal Gated Unit (MGU), and the Independently Recurrent Neural Network (IndRNN), to reduce inference times. Validation was performed against Compressed Sensing (CS) and further assessed based on data unseen during training. A pathology study was conducted by reconstructing simulated white matter lesions and prospectively undersampled data of a Multiple Sclerosis patient. Results: Training on a single modality of 3T T_1-weighted brain data appeared sufficient to also reconstruct 7T T_{2}^*-weighted brain and 3T T_2-weighted knee data. The IndRNN is an efficient recurrent unit, reducing inference time by 68\% compared to CS, whereas maintaining performance. The RIM was able to reconstruct lesions unseen during training more accurately than CS when trained on T_2-weighted knee data. Training on T_1-weighted brain data and on combined data slightly enhanced the signal compared to CS. Conclusion: The RIM is efficient when decreasing its complexity, which reduces the inference time, whereas still being able to reconstruct data and pathology that was unseen during training.

In lung radiotherapy, infrared cameras can track reflective objects on the chest to estimate tumor motion due to breathing, but treatment system latencies hinder radiation beam precision. Real-time recurrent learning (RTRL) is a potential solution that can learn patterns within non-stationary respiratory data but has high complexity. This study assesses the capabilities of resource-efficient online RNN algorithms, namely unbiased online recurrent optimization (UORO), sparse-1 step approximation (SnAp-1), and decoupled neural interfaces (DNI) to forecast respiratory motion during radiotherapy treatment accurately. We use time series containing the 3D positions of external markers on the chest of healthy subjects. We propose efficient implementations for SnAp-1 and DNI that compress the influence and immediate Jacobian matrices and accurately update the linear coefficients used in credit assignment estimation, respectively. Data was originally sampled at 10Hz; we resampled it at 3.33Hz and 30Hz to analyze the effect of the sampling rate on performance. We use UORO, SnAp-1, and DNI to forecast each marker's 3D position with horizons h<=2.1s (the time interval in advance for which the prediction is made) and compare them with RTRL, least mean squares, kernel support vector regression, and linear regression. RNNs trained online achieved similar or better accuracy than most previous works using larger training databases and deep learning, even though we used only the first minute of each sequence to predict motion within that exact sequence. SnAp-1 had the lowest normalized root mean square errors (nRMSEs) averaged over the horizon values considered, equal to 0.335 and 0.157, at 3.33Hz and 10.0Hz, respectively. Similarly, UORO had the lowest nRMSE at 30Hz, equal to 0.086. DNI's inference time (6.8ms per time step at 30Hz, Intel Core i7-13700 CPU) was the lowest among the RNN methods.

Segmenting stroke lesions in Magnetic Resonance Imaging (MRI) is challenging due to diverse clinical imaging domains, with existing models struggling to generalise across different MRI acquisition parameters and sequences. In this work, we propose two novel physics-constrained approaches using synthetic quantitative MRI (qMRI) images to enhance the robustness and generalisability of segmentation models. We trained a qMRI estimation model to predict qMRI maps from MPRAGE images, which were used to simulate diverse MRI sequences for segmentation training. A second approach built upon prior work in synthetic data for stroke lesion segmentation, generating qMRI maps from a dataset of tissue labels. The proposed approaches improved over the baseline nnUNet on a variety of out-of-distribution datasets, with the second approach outperforming the prior synthetic data method.

Tagged magnetic resonance imaging (tMRI) has been employed for decades to measure the motion of tissue undergoing deformation. However, registration-based motion estimation from tMRI is difficult due to the periodic patterns in these images, particularly when the motion is large. With a larger motion the registration approach gets trapped in a local optima, leading to motion estimation errors. We introduce a novel "momenta, shooting, and correction" framework for Lagrangian motion estimation in the presence of repetitive patterns and large motion. This framework, grounded in Lie algebra and Lie group principles, accumulates momenta in the tangent vector space and employs exponential mapping in the diffeomorphic space for rapid approximation towards true optima, circumventing local optima. A subsequent correction step ensures convergence to true optima. The results on a 2D synthetic dataset and a real 3D tMRI dataset demonstrate our method's efficiency in estimating accurate, dense, and diffeomorphic 2D/3D motion fields amidst large motion and repetitive patterns.

Magnetization transfer contrast magnetic resonance fingerprinting (MTC-MRF) is a novel quantitative imaging technique that simultaneously measures several tissue parameters of semisolid macromolecule and free bulk water. In this study, we propose an Only-Train-Once MR fingerprinting (OTOM) framework that estimates the free bulk water and MTC tissue parameters from MR fingerprints regardless of MRF schedule, thereby avoiding time-consuming process such as generation of training dataset and network training according to each MRF schedule. A recurrent neural network is designed to cope with two types of variants of MRF schedules: 1) various lengths and 2) various patterns. Experiments on digital phantoms and in vivo data demonstrate that our approach can achieve accurate quantification for the water and MTC parameters with multiple MRF schedules. Moreover, the proposed method is in excellent agreement with the conventional deep learning and fitting methods. The flexible OTOM framework could be an efficient tissue quantification tool for various MRF protocols.

This paper reviews the NTIRE 2020 challenge on real image denoising with focus on the newly introduced dataset, the proposed methods and their results. The challenge is a new version of the previous NTIRE 2019 challenge on real image denoising that was based on the SIDD benchmark. This challenge is based on a newly collected validation and testing image datasets, and hence, named SIDD+. This challenge has two tracks for quantitatively evaluating image denoising performance in (1) the Bayer-pattern rawRGB and (2) the standard RGB (sRGB) color spaces. Each track ~250 registered participants. A total of 22 teams, proposing 24 methods, competed in the final phase of the challenge. The proposed methods by the participating teams represent the current state-of-the-art performance in image denoising targeting real noisy images. The newly collected SIDD+ datasets are publicly available at: https://bit.ly/siddplus_data.

Low-light image enhancement, particularly in cross-domain tasks such as mapping from the raw domain to the sRGB domain, remains a significant challenge. Many deep learning-based methods have been developed to address this issue and have shown promising results in recent years. However, single-stage methods, which attempt to unify the complex mapping across both domains, leading to limited denoising performance. In contrast, existing two-stage approaches typically overlook the characteristic of demosaicing within the Image Signal Processing (ISP) pipeline, leading to color distortions under varying lighting conditions, especially in low-light scenarios. To address these issues, we propose a novel Mamba-based method customized for low light RAW images, called RAWMamba, to effectively handle raw images with different CFAs. Furthermore, we introduce a Retinex Decomposition Module (RDM) grounded in Retinex prior, which decouples illumination from reflectance to facilitate more effective denoising and automatic non-linear exposure correction, reducing the effect of manual linear illumination enhancement. By bridging demosaicing and denoising, better enhancement for low light RAW images is achieved. Experimental evaluations conducted on public datasets SID and MCR demonstrate that our proposed RAWMamba achieves state-of-the-art performance on cross-domain mapping. The code is available at https://github.com/Cynicarlos/RetinexRawMamba.

Accurate 3D cardiac reconstruction from cine magnetic resonance imaging (cMRI) is crucial for improved cardiovascular disease diagnosis and understanding of the heart's motion. However, current cardiac MRI-based reconstruction technology used in clinical settings is 2D with limited through-plane resolution, resulting in low-quality reconstructed cardiac volumes. To better reconstruct 3D cardiac volumes from sparse 2D image stacks, we propose a morphology-guided diffusion model for 3D cardiac volume reconstruction, DMCVR, that synthesizes high-resolution 2D images and corresponding 3D reconstructed volumes. Our method outperforms previous approaches by conditioning the cardiac morphology on the generative model, eliminating the time-consuming iterative optimization process of the latent code, and improving generation quality. The learned latent spaces provide global semantics, local cardiac morphology and details of each 2D cMRI slice with highly interpretable value to reconstruct 3D cardiac shape. Our experiments show that DMCVR is highly effective in several aspects, such as 2D generation and 3D reconstruction performance. With DMCVR, we can produce high-resolution 3D cardiac MRI reconstructions, surpassing current techniques. Our proposed framework has great potential for improving the accuracy of cardiac disease diagnosis and treatment planning. Code can be accessed at https://github.com/hexiaoxiao-cs/DMCVR.

Deep learning underpins a wide range of applications in MRI, including reconstruction, artifact removal, and segmentation. However, progress has been driven largely by public datasets focused on brain and knee imaging, shaping how models are trained and evaluated. As a result, careful studies of the reliability of these models across diverse anatomical settings remain limited. In this work, we introduce MosaicMRI, a large and diverse collection of fully sampled raw musculoskeletal (MSK) MR measurements designed for training and evaluating machine-learning-based methods. MosaicMRI is the largest open-source raw MSK MRI dataset to date, comprising 2,671 volumes and 80,156 slices. The dataset offers substantial diversity in volume orientation (e.g., axial, sagittal), imaging contrasts (e.g., PD, T1, T2), anatomies (e.g., spine, knee, hip, ankle, and others), and numbers of acquisition coils. Using VarNet as a baseline for accelerated reconstruction task, we perform a comprehensive set of experiments to study scaling behavior with respect to both model capacity and dataset size. Interestingly, models trained on the combined anatomies significantly outperform anatomy-specific models in low-sample regimes, highlighting the benefits of anatomical diversity and the presence of exploitable cross-anatomical correlations. We further evaluate robustness and cross-anatomy generalization by training models on one anatomy (e.g., spine) and testing them on another (e.g., knee). Notably, we identify groups of body parts (e.g., foot and elbow) that generalize well with each other, and highlight that performance under domain shifts depends on both training set size, anatomy, and protocol-specific factors.

Text-to-Image (T2I) models have recently seen notable progress around 1K and 2K resolution. With the extreme desire for better visual experience and the rapid development of imaging technology, the demand for Ultra-High-Resolution (UHR) image generation has grown significantly. However, UHR image generation poses great challenges due to the scarcity and complexity of high-resolution content. In this paper, we first introduce PixVerve-95K, a high-quality, open-source UHR T2I dataset curated with a carefully designed data pipeline, which contains 95K images across diverse scenarios (each image has a minimum pixel-count of 100M) and seven-dimensional annotations. Based on our large-scale image-text dataset, we take a pioneering step to extend various T2I foundation models to native 100MP generation with three training schemes. Finally, leveraging both conventional metrics and multimodal large language model-based assessments, our proposed PixVerve-Bench benchmark establishes a comprehensive evaluation protocol for UHR images encompassing visual quality and semantic alignment. Extensive experimental results on our benchmark and the constructive exploration of training strategies collaboratively provide valuable insights for future breakthroughs.

Text-to-Image (T2I) and multimodal large language models (MLLMs) have been adopted in solutions for several computer vision and multimodal learning tasks. However, it has been found that such vision-language models lack the ability to correctly reason over spatial relationships. To tackle this shortcoming, we develop the REVISION framework which improves spatial fidelity in vision-language models. REVISION is a 3D rendering based pipeline that generates spatially accurate synthetic images, given a textual prompt. REVISION is an extendable framework, which currently supports 100+ 3D assets, 11 spatial relationships, all with diverse camera perspectives and backgrounds. Leveraging images from REVISION as additional guidance in a training-free manner consistently improves the spatial consistency of T2I models across all spatial relationships, achieving competitive performance on the VISOR and T2I-CompBench benchmarks. We also design RevQA, a question-answering benchmark to evaluate the spatial reasoning abilities of MLLMs, and find that state-of-the-art models are not robust to complex spatial reasoning under adversarial settings. Our results and findings indicate that utilizing rendering-based frameworks is an effective approach for developing spatially-aware generative models.

Clinical MRI encompasses diverse imaging protocols--spanning anatomical targets (cardiac, brain, knee), contrasts (T1, T2, mapping), sampling patterns (Cartesian, radial, spiral, kt-space), and acceleration factors--yet current deep learning reconstructions are typically protocol-specific, hindering generalization and deployment. We introduce Scalable Deep Unrolled Model (SDUM), a universal framework combining a Restormer-based reconstructor, a learned coil sensitivity map estimator (CSME), sampling-aware weighted data consistency (SWDC), universal conditioning (UC) on cascade index and protocol metadata, and progressive cascade expansion training. SDUM exhibits foundation-model-like scaling behavior: reconstruction quality follows PSNR {sim} log(parameters) with correlation r{=}0.986 (R^2{=}0.973) up to 18 cascades, demonstrating predictable performance gains with model depth. A single SDUM trained on heterogeneous data achieves state-of-the-art results across all four CMRxRecon2025 challenge tracks--multi-center, multi-disease, 5T, and pediatric--without task-specific fine-tuning, surpassing specialized baselines by up to {+}1.0~dB. On CMRxRecon2024, SDUM outperforms the winning method PromptMR+ by {+}0.55~dB; on fastMRI brain, it exceeds PC-RNN by {+}1.8~dB. Ablations validate each component: SWDC {+}0.43~dB over standard DC, per-cascade CSME {+}0.51~dB, UC {+}0.38~dB. These results establish SDUM as a practical path toward universal, scalable MRI reconstruction.

Recent progress in text-to-image (T2I) generation underscores the importance of reliable benchmarks in evaluating how accurately generated images reflect the semantics of their textual prompt. However, (1) existing benchmarks lack the diversity of prompt scenarios and multilingual support, both essential for real-world applicability; (2) they offer only coarse evaluations across primary dimensions, covering a narrow range of sub-dimensions, and fall short in fine-grained sub-dimension assessment. To address these limitations, we introduce UniGenBench++, a unified semantic assessment benchmark for T2I generation. Specifically, it comprises 600 prompts organized hierarchically to ensure both coverage and efficiency: (1) spans across diverse real-world scenarios, i.e., 5 main prompt themes and 20 subthemes; (2) comprehensively probes T2I models' semantic consistency over 10 primary and 27 sub evaluation criteria, with each prompt assessing multiple testpoints. To rigorously assess model robustness to variations in language and prompt length, we provide both English and Chinese versions of each prompt in short and long forms. Leveraging the general world knowledge and fine-grained image understanding capabilities of a closed-source Multi-modal Large Language Model (MLLM), i.e., Gemini-2.5-Pro, an effective pipeline is developed for reliable benchmark construction and streamlined model assessment. Moreover, to further facilitate community use, we train a robust evaluation model that enables offline assessment of T2I model outputs. Through comprehensive benchmarking of both open- and closed-sourced T2I models, we systematically reveal their strengths and weaknesses across various aspects.

Accelerating MRI scans is one of the principal outstanding problems in the MRI research community. Towards this goal, we hosted the second fastMRI competition targeted towards reconstructing MR images with subsampled k-space data. We provided participants with data from 7,299 clinical brain scans (de-identified via a HIPAA-compliant procedure by NYU Langone Health), holding back the fully-sampled data from 894 of these scans for challenge evaluation purposes. In contrast to the 2019 challenge, we focused our radiologist evaluations on pathological assessment in brain images. We also debuted a new Transfer track that required participants to submit models evaluated on MRI scanners from outside the training set. We received 19 submissions from eight different groups. Results showed one team scoring best in both SSIM scores and qualitative radiologist evaluations. We also performed analysis on alternative metrics to mitigate the effects of background noise and collected feedback from the participants to inform future challenges. Lastly, we identify common failure modes across the submissions, highlighting areas of need for future research in the MRI reconstruction community.

Incentivizing the reasoning ability of Multimodal Large Language Models (MLLMs) is essential for medical applications to transparently analyze medical scans and provide reliable diagnosis. However, existing medical MLLMs rely solely on internal knowledge during reasoning, leading to hallucinated reasoning and factual inaccuracies when encountering cases beyond their training scope. Although recent Agentic Retrieval-Augmented Generation (RAG) methods elicit the medical model's proactive retrieval ability during reasoning, they are confined to unimodal LLMs, neglecting the crucial visual information during reasoning and retrieval. Consequently, we propose the first Multimodal Medical Reasoning-with-Retrieval framework, Med-RwR, which actively retrieves external knowledge by querying observed symptoms or domain-specific medical concepts during reasoning. Specifically, we design a two-stage reinforcement learning strategy with tailored rewards that stimulate the model to leverage both visual diagnostic findings and textual clinical information for effective retrieval. Building on this foundation, we further propose a Confidence-Driven Image Re-retrieval (CDIR) method for test-time scaling when low prediction confidence is detected. Evaluation on various public medical benchmarks demonstrates Med-RwR's significant improvements over baseline models, proving the effectiveness of enhancing reasoning capabilities with external knowledge integration. Furthermore, Med-RwR demonstrates remarkable generalizability to unfamiliar domains, evidenced by 8.8% performance gain on our proposed EchoCardiography Benchmark (ECBench), despite the scarcity of echocardiography data in the training corpus. Our data, model, and codes will be made publicly available at https://github.com/xmed-lab/Med-RwR.

Diffusion-weighted magnetic resonance imaging (DW-MRI) can be used to characterise the microstructure of the nervous tissue, e.g. to delineate brain white matter connections in a non-invasive manner via fibre tracking. Magnetic Resonance Imaging (MRI) in high spatial resolution would play an important role in visualising such fibre tracts in a superior manner. However, obtaining an image of such resolution comes at the expense of longer scan time. Longer scan time can be associated with the increase of motion artefacts, due to the patient's psychological and physical conditions. Single Image Super-Resolution (SISR), a technique aimed to obtain high-resolution (HR) details from one single low-resolution (LR) input image, achieved with Deep Learning, is the focus of this study. Compared to interpolation techniques or sparse-coding algorithms, deep learning extracts prior knowledge from big datasets and produces superior MRI images from the low-resolution counterparts. In this research, a deep learning based super-resolution technique is proposed and has been applied for DW-MRI. Images from the IXI dataset have been used as the ground-truth and were artificially downsampled to simulate the low-resolution images. The proposed method has shown statistically significant improvement over the baselines and achieved an SSIM of 0.913pm0.045.

Converting free-text cardiac magnetic resonance (CMR) reports into auditable structured data remains a bottleneck for cohort assembly, longitudinal curation, and clinical decision support. We present CMR-EXTR, a lightweight framework that converts free-text CMR reports into structured data and assigns per-field confidence for quality control. A teacher-student distillation pipeline enables fully offline inference while limiting manual annotation. Uncertainty integrates three complementary principles -- distribution plausibility, sampling stability, and cross-field consistency -- to triage human review. Experiments show that CMR-EXTR achieves 99.65% variable-level accuracy, demonstrating both reliable extraction and informative confidence scores. To our knowledge, this is the first CMR-specific extraction system with integrated confidence estimation. The code is available at https://github.com/yuyi1005/CMR-EXTR.

Recent advancements in text-to-image (T2I) generation models have transformed the field. However, challenges persist in generating images that reflect demanding textual descriptions, especially for fine-grained details and unusual relationships. Existing evaluation metrics focus on text-image alignment but overlook the realism of the generated image, which can be crucial for downstream applications like data augmentation in machine learning. To address this gap, we propose REAL, an automatic evaluation framework that assesses realism of T2I outputs along three dimensions: fine-grained visual attributes, unusual visual relationships, and visual styles. REAL achieves a Spearman's rho score of up to 0.62 in alignment with human judgement and demonstrates utility in ranking and filtering augmented data for tasks like image captioning, classification, and visual relationship detection. Empirical results show that high-scoring images evaluated by our metrics improve F1 scores of image classification by up to 11.3%, while low-scoring ones degrade that by up to 4.95%. We benchmark four major T2I models across the realism dimensions, providing insights for future improvements in T2I output realism.

Magnetic resonance imaging (MRI) is a cornerstone of modern medical imaging. However, long image acquisition times, the need for qualitative expert analysis, and the lack of (and difficulty extracting) quantitative indicators that are sensitive to tissue health have curtailed widespread clinical and research studies. While recent machine learning methods for MRI reconstruction and analysis have shown promise for reducing this burden, these techniques are primarily validated with imperfect image quality metrics, which are discordant with clinically-relevant measures that ultimately hamper clinical deployment and clinician trust. To mitigate this challenge, we present the Stanford Knee MRI with Multi-Task Evaluation (SKM-TEA) dataset, a collection of quantitative knee MRI (qMRI) scans that enables end-to-end, clinically-relevant evaluation of MRI reconstruction and analysis tools. This 1.6TB dataset consists of raw-data measurements of ~25,000 slices (155 patients) of anonymized patient MRI scans, the corresponding scanner-generated DICOM images, manual segmentations of four tissues, and bounding box annotations for sixteen clinically relevant pathologies. We provide a framework for using qMRI parameter maps, along with image reconstructions and dense image labels, for measuring the quality of qMRI biomarker estimates extracted from MRI reconstruction, segmentation, and detection techniques. Finally, we use this framework to benchmark state-of-the-art baselines on this dataset. We hope our SKM-TEA dataset and code can enable a broad spectrum of research for modular image reconstruction and image analysis in a clinically informed manner. Dataset access, code, and benchmarks are available at https://github.com/StanfordMIMI/skm-tea.

The insufficient number of annotated thermal infrared (TIR) image datasets not only hinders TIR image-based deep learning networks to have comparable performances to that of RGB but it also limits the supervised learning of TIR image-based tasks with challenging labels. As a remedy, we propose a modified multidomain RGB to TIR image translation model focused on edge preservation to employ annotated RGB images with challenging labels. Our proposed method not only preserves key details in the original image but also leverages the optimal TIR style code to portray accurate TIR characteristics in the translated image, when applied on both synthetic and real world RGB images. Using our translation model, we have enabled the supervised learning of deep TIR image-based optical flow estimation and object detection that ameliorated in deep TIR optical flow estimation by reduction in end point error by 56.5\% on average and the best object detection mAP of 23.9\% respectively. Our code and supplementary materials are available at https://github.com/rpmsnu/sRGB-TIR.

Hyperthermia (HT) in combination with radio- and/or chemotherapy has become an accepted cancer treatment for distinct solid tumour entities. In HT, tumour tissue is exogenously heated to temperatures between 39 and 43 ^circC for 60 minutes. Temperature monitoring can be performed non-invasively using dynamic magnetic resonance imaging (MRI). However, the slow nature of MRI leads to motion artefacts in the images due to the movements of patients during image acquisition. By discarding parts of the data, the speed of the acquisition can be increased - known as undersampling. However, due to the invalidation of the Nyquist criterion, the acquired images might be blurry and can also produce aliasing artefacts. The aim of this work was, therefore, to reconstruct highly undersampled MR thermometry acquisitions with better resolution and with fewer artefacts compared to conventional methods. The use of deep learning in the medical field has emerged in recent times, and various studies have shown that deep learning has the potential to solve inverse problems such as MR image reconstruction. However, most of the published work only focuses on the magnitude images, while the phase images are ignored, which are fundamental requirements for MR thermometry. This work, for the first time, presents deep learning-based solutions for reconstructing undersampled MR thermometry data. Two different deep learning models have been employed here, the Fourier Primal-Dual network and the Fourier Primal-Dual UNet, to reconstruct highly undersampled complex images of MR thermometry. The method reduced the temperature difference between the undersampled MRIs and the fully sampled MRIs from 1.3 ^circC to 0.6 ^circC in full volume and 0.49 ^circC to 0.06 ^circC in the tumour region for an acceleration factor of 10.

Despite impressive performance on standard benchmarks, multimodal large language models (MLLMs) face critical challenges in real-world clinical environments where medical images inevitably suffer various quality degradations. Existing benchmarks exhibit two key limitations: (1) absence of large-scale, multidimensional assessment across medical image quality gradients and (2) no systematic confidence calibration analysis. To address these gaps, we present MedQ-Deg, a comprehensive benchmark for evaluating medical MLLMs under image quality degradations. MedQ-Deg provides multi-dimensional evaluation spanning 18 distinct degradation types, 30 fine-grained capability dimensions, and 7 imaging modalities, with 24,894 question-answer pairs. Each degradation is implemented at 3 severity degrees, calibrated by expert radiologists. We further introduce Calibration Shift metric, which quantifies the gap between a model's perceived confidence and actual performance to assess metacognitive reliability under degradation. Our comprehensive evaluation of 40 mainstream MLLMs reveals several critical findings: (1) overall model performance degrades systematically as degradation severity increases, (2) models universally exhibit the AI Dunning-Kruger Effect, maintaining inappropriately high confidence despite severe accuracy collapse, and (3) models display markedly differentiated behavioral patterns across capability dimensions, imaging modalities, and degradation types. We hope MedQ-Deg drives progress toward medical MLLMs that are robust and trustworthy in real clinical practice.

In medical imaging, vision-language models face a critical duality: pretrained networks offer broad robustness but lack subtle, modality-specific characteristics, while fine-tuned expert models achieve high in-distribution accuracy yet falter under modality shift. Existing model-merging techniques, designed for natural-image benchmarks, are simple and efficient but fail to deliver consistent gains across diverse medical modalities; their static interpolation limits reliability in varied clinical tasks. To address this, we introduce Test-Time Task adaptive merging (T^3), a backpropagation-free framework that computes per-sample interpolation coefficients via the Jensen-Shannon divergence between the two models' output distributions. T^3 dynamically preserves local precision when models agree and defers to generalist robustness under drift. To overcome the inference costs of sample-wise merging, we further propose a batch-wise extension, T^3_B, that computes a merging coefficient across a batch of samples, dramatically reducing computational bottleneck. Recognizing the lack of a standardized medical-merging benchmark, we present a rigorous cross-evaluation protocol spanning in-domain, base-to-novel, and corruptions across four modalities. Empirically, T^3 sets new state-of-the-art in Top-1 accuracy and error reduction, outperforming strong baselines while maintaining efficiency, paving the way for adaptive MVLM deployment in clinical settings. Our code is available at https://github.com/Razaimam45/TCube.

Text-to-Image (T2I) models have made significant advancements in recent years, but they still struggle to accurately capture intricate details specified in complex compositional prompts. While fine-tuning T2I models with reward objectives has shown promise, it suffers from "reward hacking" and may not generalize well to unseen prompt distributions. In this work, we propose Reward-based Noise Optimization (ReNO), a novel approach that enhances T2I models at inference by optimizing the initial noise based on the signal from one or multiple human preference reward models. Remarkably, solving this optimization problem with gradient ascent for 50 iterations yields impressive results on four different one-step models across two competitive benchmarks, T2I-CompBench and GenEval. Within a computational budget of 20-50 seconds, ReNO-enhanced one-step models consistently surpass the performance of all current open-source Text-to-Image models. Extensive user studies demonstrate that our model is preferred nearly twice as often compared to the popular SDXL model and is on par with the proprietary Stable Diffusion 3 with 8B parameters. Moreover, given the same computational resources, a ReNO-optimized one-step model outperforms widely-used open-source models such as SDXL and PixArt-alpha, highlighting the efficiency and effectiveness of ReNO in enhancing T2I model performance at inference time. Code is available at https://github.com/ExplainableML/ReNO.

Medical vision-language pretraining increasingly relies on medical reports as large-scale supervisory signals; however, raw reports often exhibit substantial stylistic heterogeneity, variable length, and a considerable amount of image-irrelevant content. Although text normalization is frequently adopted as a preprocessing step in prior work, its design principles and empirical impact on vision-language pretraining remain insufficiently and systematically examined. In this study, we present MedTri, a deployable normalization framework for medical vision-language pretraining that converts free-text reports into a unified [Anatomical Entity: Radiologic Description + Diagnosis Category] triplet. This structured, anatomy-grounded normalization preserves essential morphological and spatial information while removing stylistic noise and image-irrelevant content, providing consistent and image-grounded textual supervision at scale. Across multiple datasets spanning both X-ray and computed tomography (CT) modalities, we demonstrate that structured, anatomy-grounded text normalization is an important factor in medical vision-language pretraining quality, yielding consistent improvements over raw reports and existing normalization baselines. In addition, we illustrate how this normalization can easily support modular text-level augmentation strategies, including knowledge enrichment and anatomy-grounded counterfactual supervision, which provide complementary gains in robustness and generalization without altering the core normalization process. Together, our results position structured text normalization as a critical and generalizable preprocessing component for medical vision-language learning, while MedTri provides this normalization platform. Code and data will be released at https://github.com/Arturia-Pendragon-Iris/MedTri.

Self-supervised deep learning has accelerated 2D natural image analysis but remains difficult to translate into 3D MRI, where data are scarce and pre-trained 2D backbones cannot capture volumetric context. We present a sequence-invariant self-supervised framework leveraging quantitative MRI (qMRI). By simulating multiple MRI contrasts from a single 3D qMRI scan and enforcing consistent representations across these contrasts, we learn anatomy-centric rather than sequence-specific features. The result is a single 3D encoder that excels across tasks and protocols. Experiments on healthy brain segmentation (IXI), stroke lesion segmentation (ARC), and MRI denoising show significant gains over baseline SSL approaches, especially in low-data settings (up to +8.3\% Dice, +4.2 dB PSNR). It also generalises to unseen sites, supporting scalable clinical use. Code and trained models are publicly available at https://github.com/liamchalcroft/contrast-squared

We introduce MMTR-Bench, a benchmark designed to evaluate the intrinsic ability of Multimodal Large Language Models (MLLMs) to reconstruct masked text directly from visual context. Unlike conventional question-answering tasks, MMTR-Bench eliminates explicit prompts, requiring models to recover masked text from single- or multi-page inputs across real-world domains such as documents and webpages. This design isolates the reconstruction task from instruction-following abilities, enabling a direct assessment of a model's layout understanding, visual grounding, and knowledge integration. MMTR-Bench comprises 2,771 test samples spanning multiple languages and varying target lengths. To account for this diversity, we propose a level-aware evaluation protocol. Experiments on representative MLLMs show that the benchmark poses a significant challenge, especially for sentence- and paragraph-level reconstruction. The homepage is available at https://mmtr-bench-dataset.github.io/MMTR-Bench/.

Most visual models are designed for sRGB images, yet RAW data offers significant advantages for object detection by preserving sensor information before ISP processing. This enables improved detection accuracy and more efficient hardware designs by bypassing the ISP. However, RAW object detection is challenging due to limited training data, unbalanced pixel distributions, and sensor noise. To address this, we propose SimROD, a lightweight and effective approach for RAW object detection. We introduce a Global Gamma Enhancement (GGE) module, which applies a learnable global gamma transformation with only four parameters, improving feature representation while keeping the model efficient. Additionally, we leverage the green channel's richer signal to enhance local details, aligning with the human eye's sensitivity and Bayer filter design. Extensive experiments on multiple RAW object detection datasets and detectors demonstrate that SimROD outperforms state-of-the-art methods like RAW-Adapter and DIAP while maintaining efficiency. Our work highlights the potential of RAW data for real-world object detection. Code is available at https://ocean146.github.io/SimROD2025/.

Accurate quantification of lung disease severity from chest imaging is critical for clinical decision-making and resource allocation. We propose a tri-modal deep learning framework, TMF-RSE (Tri-Modal Fusion with Regional Semantics and Evidential Uncertainty), that combines appearance features from two-dimensional chest inputs, structural features from lung segmentation masks, and semantic features from vision-language models (VLMs) for severity quantification. Our approach employs complementary fusion mechanisms that integrate semantic guidance, structural priors, and hierarchical interactions across modalities. The model employs evidential regression to provide both severity predictions and uncertainty estimates. Experiments on the Per-COVID-19 CT and RALO datasets show that TMF-RSE outperforms recent transformer-based baselines, achieving MAE of 4.02 and Pearson correlation of 0.9629 on Per-COVID-19 validation, and 0.339 MAE / 0.973 PC on RALO geographic extent.

Machine Learning methods can learn how to reconstruct Magnetic Resonance Images and thereby accelerate acquisition, which is of paramount importance to the clinical workflow. Physics-informed networks incorporate the forward model of accelerated MRI reconstruction in the learning process. With increasing network complexity, robustness is not ensured when reconstructing data unseen during training. We aim to embed data consistency (DC) in deep networks while balancing the degree of network complexity. While doing so, we will assess whether either explicit or implicit enforcement of DC in varying network architectures is preferred to optimize performance. We propose a scheme called Cascades of Independently Recurrent Inference Machines (CIRIM) to assess DC through unrolled optimization. Herein we assess DC both implicitly by gradient descent and explicitly by a designed term. Extensive comparison of the CIRIM to CS as well as to other methods is performed: the E2EVN, CascadeNet, KIKINet, LPDNet, RIM, IRIM, and UNet. Models were trained and evaluated on T1-weighted and FLAIR contrast brain data, and T2-weighted knee data. Both 1D and 2D undersampling patterns were evaluated. Robustness was tested by reconstructing 7.5x prospectively undersampled 3D FLAIR MRI data of Multiple Sclerosis (MS) patients with white matter lesions. The CIRIM performed best when implicitly enforcing DC, while the E2EVN required an explicit DC formulation. In reconstructing MS patient data, prospectively acquired with a sampling pattern unseen during model training, the CIRIM maintained lesion contrast while efficiently denoising the images. The CIRIM showed highly promising generalization capabilities maintaining a very fair trade-off between reconstructed image quality and fast reconstruction times, which is crucial in the clinical workflow.

Deep-learning-based brain magnetic resonance imaging (MRI) reconstruction methods have the potential to accelerate the MRI acquisition process. Nevertheless, the scientific community lacks appropriate benchmarks to assess MRI reconstruction quality of high-resolution brain images, and evaluate how these proposed algorithms will behave in the presence of small, but expected data distribution shifts. The Multi-Coil Magnetic Resonance Image (MC-MRI) Reconstruction Challenge provides a benchmark that aims at addressing these issues, using a large dataset of high-resolution, three-dimensional, T1-weighted MRI scans. The challenge has two primary goals: 1) to compare different MRI reconstruction models on this dataset and 2) to assess the generalizability of these models to data acquired with a different number of receiver coils. In this paper, we describe the challenge experimental design, and summarize the results of a set of baseline and state of the art brain MRI reconstruction models. We provide relevant comparative information on the current MRI reconstruction state-of-the-art and highlight the challenges of obtaining generalizable models that are required prior to broader clinical adoption. The MC-MRI benchmark data, evaluation code and current challenge leaderboard are publicly available. They provide an objective performance assessment for future developments in the field of brain MRI reconstruction.

This paper presents a comprehensive review of the NTIRE 2025 Challenge on Single-Image Efficient Super-Resolution (ESR). The challenge aimed to advance the development of deep models that optimize key computational metrics, i.e., runtime, parameters, and FLOPs, while achieving a PSNR of at least 26.90 dB on the DIV2K_LSDIR_valid dataset and 26.99 dB on the DIV2K_LSDIR_test dataset. A robust participation saw 244 registered entrants, with 43 teams submitting valid entries. This report meticulously analyzes these methods and results, emphasizing groundbreaking advancements in state-of-the-art single-image ESR techniques. The analysis highlights innovative approaches and establishes benchmarks for future research in the field.

In material sciences, characterizing faults in periodic structures is vital for understanding material properties. To characterize magnetic labyrinthine patterns, it is necessary to accurately identify junctions and terminals, often featuring over a thousand closely packed defects per image. This study introduces a new technique called TM-CNN (Template Matching - Convolutional Neural Network) designed to detect a multitude of small objects in images, such as defects in magnetic labyrinthine patterns. TM-CNN was used to identify these structures in 444 experimental images, and the results were explored to deepen the understanding of magnetic materials. It employs a two-stage detection approach combining template matching, used in initial detection, with a convolutional neural network, used to eliminate incorrect identifications. To train a CNN classifier, it is necessary to create a large number of training images. This difficulty prevents the use of CNN in many practical applications. TM-CNN significantly reduces the manual workload for creating training images by automatically making most of the annotations and leaving only a small number of corrections to human reviewers. In testing, TM-CNN achieved an impressive F1 score of 0.988, far outperforming traditional template matching and CNN-based object detection algorithms.

Accelerated magnetic resonance (MR) imaging attempts to reduce acquisition time by collecting data below the Nyquist rate. As an ill-posed inverse problem, many plausible solutions exist, yet the majority of deep learning approaches generate only a single solution. We instead focus on sampling from the posterior distribution, which provides more comprehensive information for downstream inference tasks. To do this, we design a novel conditional normalizing flow (CNF) that infers the signal component in the measurement operator's nullspace, which is later combined with measured data to form complete images. Using fastMRI brain and knee data, we demonstrate fast inference and accuracy that surpasses recent posterior sampling techniques for MRI. Code is available at https://github.com/jwen307/mri_cnf/

Handwriting recognition has seen significant success with the use of deep learning. However, a persistent shortcoming of neural networks is that they are not well-equipped to deal with shifting data distributions. In the field of handwritten text recognition (HTR), this shows itself in poor recognition accuracy for writers that are not similar to those seen during training. An ideal HTR model should be adaptive to new writing styles in order to handle the vast amount of possible writing styles. In this paper, we explore how HTR models can be made writer adaptive by using only a handful of examples from a new writer (e.g., 16 examples) for adaptation. Two HTR architectures are used as base models, using a ResNet backbone along with either an LSTM or Transformer sequence decoder. Using these base models, two methods are considered to make them writer adaptive: 1) model-agnostic meta-learning (MAML), an algorithm commonly used for tasks such as few-shot classification, and 2) writer codes, an idea originating from automatic speech recognition. Results show that an HTR-specific version of MAML known as MetaHTR improves performance compared to the baseline with a 1.4 to 2.0 improvement in word error rate (WER). The improvement due to writer adaptation is between 0.2 and 0.7 WER, where a deeper model seems to lend itself better to adaptation using MetaHTR than a shallower model. However, applying MetaHTR to larger HTR models or sentence-level HTR may become prohibitive due to its high computational and memory requirements. Lastly, writer codes based on learned features or Hinge statistical features did not lead to improved recognition performance.

Recent large vision-language models (LVLMs) have been applied to diverse VQA tasks. However, achieving practical performance typically requires task-specific fine-tuning with large numbers of image-text pairs, which are costly to collect. In this work, we study text-centric training, a setting where only textual descriptions are available and no real images are provided, as a paradigm for low-cost data scaling. Unlike images, whose collection is often restricted by privacy constraints and scarcity in niche domains, text is widely available. Moreover, text is easily editable, enabling automatic diversification and expansion with LLMs at minimal human effort. While this offers clear advantages over image collection in terms of scalability and cost, training on raw text without images still yields limited gains on VQA tasks because of the image-text modality gap. To address this issue, we propose a Text-Printed Image (TPI), which generates synthetic images by directly rendering the given textual description on a plain white canvas. This simple rendering projects text into the image modality and can be integrated into arbitrary existing LVLM training pipelines at low cost. Moreover, TPI preserves the semantics of the text, whereas text-to-image models often fail to do. Across four models and seven benchmarks, our systematic experiments show that TPI enables more effective text-centric training than synthetic images generated by a diffusion model. We further explore TPI as a low-cost data-augmentation strategy and demonstrate its practical utility. Overall, our findings highlight the significant potential of text-centric training and, more broadly, chart a path toward fully automated data generation for LVLMs.

Text-to-image (T2I) models are well known for their ability to produce highly realistic images, while multimodal large language models (MLLMs) are renowned for their proficiency in understanding and integrating multiple modalities. However, currently there is no straightforward and efficient framework to transfer the multimodal comprehension abilities of MLLMs to T2I models to enable them to understand multimodal inputs. In this paper, we propose the X2I framework, which endows Diffusion Transformer (DiT) models with the capability to comprehend various modalities, including multilingual text, screenshot documents, images, videos, and audio. X2I is trained using merely 100K English corpus with 160 GPU hours. Building on the DiT teacher model, we adopt an innovative distillation method to extract the inference capabilities of the teacher model and design a lightweight AlignNet structure to serve as an intermediate bridge. Compared to the teacher model, X2I shows a decrease in performance degradation of less than 1\% while gaining various multimodal understanding abilities, including multilingual to image, image to image, image-text to image, video to image, audio to image, and utilizing creative fusion to enhance imagery. Furthermore, it is applicable for LoRA training in the context of image-text to image generation, filling a void in the industry in this area. We further design a simple LightControl to enhance the fidelity of instructional image editing. Finally, extensive experiments demonstrate the effectiveness, efficiency, multifunctionality, and transferability of our X2I. The open-source code and checkpoints for X2I can be found at the following link: https://github.com/OPPO-Mente-Lab/X2I.

Large-scale text encoders in text-to-image (T2I) diffusion models have demonstrated exceptional performance in generating high-quality images from textual prompts. Unlike denoising modules that rely on multiple iterative steps, text encoders require only a single forward pass to produce text embeddings. However, despite their minimal contribution to total inference time and floating-point operations (FLOPs), text encoders demand significantly higher memory usage, up to eight times more than denoising modules. To address this inefficiency, we propose Skip and Re-use layers (Skrr), a simple yet effective pruning strategy specifically designed for text encoders in T2I diffusion models. Skrr exploits the inherent redundancy in transformer blocks by selectively skipping or reusing certain layers in a manner tailored for T2I tasks, thereby reducing memory consumption without compromising performance. Extensive experiments demonstrate that Skrr maintains image quality comparable to the original model even under high sparsity levels, outperforming existing blockwise pruning methods. Furthermore, Skrr achieves state-of-the-art memory efficiency while preserving performance across multiple evaluation metrics, including the FID, CLIP, DreamSim, and GenEval scores.

Despite the stunning ability to generate high-quality images by recent text-to-image models, current approaches often struggle to effectively compose objects with different attributes and relationships into a complex and coherent scene. We propose T2I-CompBench, a comprehensive benchmark for open-world compositional text-to-image generation, consisting of 6,000 compositional text prompts from 3 categories (attribute binding, object relationships, and complex compositions) and 6 sub-categories (color binding, shape binding, texture binding, spatial relationships, non-spatial relationships, and complex compositions). We further propose several evaluation metrics specifically designed to evaluate compositional text-to-image generation. We introduce a new approach, Generative mOdel fine-tuning with Reward-driven Sample selection (GORS), to boost the compositional text-to-image generation abilities of pretrained text-to-image models. Extensive experiments and evaluations are conducted to benchmark previous methods on T2I-CompBench, and to validate the effectiveness of our proposed evaluation metrics and GORS approach. Project page is available at https://karine-h.github.io/T2I-CompBench/.

We present TMMLU+, a new benchmark designed for Traditional Chinese language understanding. TMMLU+ is a multi-choice question-answering dataset with 66 subjects from elementary to professional level. It is six times larger and boasts a more balanced subject distribution than its predecessor, Taiwan Massive Multitask Language Understanding (TMMLU). We also benchmark closed-source models and 26 open-weight Chinese large language models (LLMs) of parameters ranging from 1.8B to 72B on the proposed TMMLU+. Our findings reveal that (1.) Traditional Chinese models still trail behind their Simplified Chinese counterparts, highlighting a need for more focused advancements in LLMs catering to Traditional Chinese. (2.) Current LLMs still fall short of human performance in average scores, indicating a potential need for future research to delve deeper into social science and humanities subjects. (3.) Among all the tokenization compression metrics examined, we identify that only the fertility score uniquely demonstrates strong correlations with our benchmark results. We foresee that TMMLU+ will pinpoint areas for future model improvement, thereby narrowing the gap between machine and human linguistic capabilities and supporting researchers in developing Traditional Chinese LLMs. Our dataset, along with the benchmark source code, is accessible at huggingface.co/datasets/ikala/tmmluplus.

Conventional cameras capture image irradiance on a sensor and convert it to RGB images using an image signal processor (ISP). The images can then be used for photography or visual computing tasks in a variety of applications, such as public safety surveillance and autonomous driving. One can argue that since RAW images contain all the captured information, the conversion of RAW to RGB using an ISP is not necessary for visual computing. In this paper, we propose a novel ρ-Vision framework to perform high-level semantic understanding and low-level compression using RAW images without the ISP subsystem used for decades. Considering the scarcity of available RAW image datasets, we first develop an unpaired CycleR2R network based on unsupervised CycleGAN to train modular unrolled ISP and inverse ISP (invISP) models using unpaired RAW and RGB images. We can then flexibly generate simulated RAW images (simRAW) using any existing RGB image dataset and finetune different models originally trained for the RGB domain to process real-world camera RAW images. We demonstrate object detection and image compression capabilities in RAW-domain using RAW-domain YOLOv3 and RAW image compressor (RIC) on snapshots from various cameras. Quantitative results reveal that RAW-domain task inference provides better detection accuracy and compression compared to RGB-domain processing. Furthermore, the proposed ho-Vision generalizes across various camera sensors and different task-specific models. Additional advantages of the proposed ρ-Vision that eliminates the ISP are the potential reductions in computations and processing times.

Radiology report generation (RRG) is a challenging task, as it requires a thorough understanding of medical images, integration of multiple temporal inputs, and accurate report generation. Effective interpretation of medical images, such as chest X-rays (CXRs), demands sophisticated visual-language reasoning to map visual findings to structured reports. Recent studies have shown that multimodal large language models (MLLMs) can acquire multimodal capabilities by aligning with pre-trained vision encoders. However, current approaches predominantly focus on single-image analysis or utilise rule-based symbolic processing to handle multiple images, thereby overlooking the essential temporal information derived from comparing current images with prior ones. To overcome this critical limitation, we introduce Libra, a temporal-aware MLLM tailored for CXR report generation using temporal images. Libra integrates a radiology-specific image encoder with a MLLM and utilises a novel Temporal Alignment Connector to capture and synthesise temporal information of images across different time points with unprecedented precision. Extensive experiments show that Libra achieves new state-of-the-art performance among the same parameter scale MLLMs for RRG tasks on the MIMIC-CXR. Specifically, Libra improves the RadCliQ metric by 12.9% and makes substantial gains across all lexical metrics compared to previous models.

Tangent Model Composition (TMC) is a method to combine component models independently fine-tuned around a pre-trained point. Component models are tangent vectors to the pre-trained model that can be added, scaled, or subtracted to support incremental learning, ensembling, or unlearning. Component models are composed at inference time via scalar combination, reducing the cost of ensembling to that of a single model. TMC improves accuracy by 4.2% compared to ensembling non-linearly fine-tuned models at a 2.5x to 10x reduction of inference cost, growing linearly with the number of component models. Each component model can be forgotten at zero cost, with no residual effect on the resulting inference. When used for continual fine-tuning, TMC is not constrained by sequential bias and can be executed in parallel on federated data. TMC outperforms recently published continual fine-tuning methods almost uniformly on each setting -- task-incremental, class-incremental, and data-incremental -- on a total of 13 experiments across 3 benchmark datasets, despite not using any replay buffer. TMC is designed for composing models that are local to a pre-trained embedding, but could be extended to more general settings.

The rapid development of text-to-image (T2I) generation approaches has attracted extensive interest in evaluating the quality of generated images, leading to the development of various quality assessment methods for general-purpose T2I outputs. However, existing image quality assessment (IQA) methods are limited to providing global quality scores, failing to deliver fine-grained perceptual evaluations for structurally complex subjects like humans, which is a critical challenge considering the frequent anatomical and textural distortions in AI-generated human images (AGHIs). To address this gap, we introduce AGHI-QA, the first large-scale benchmark specifically designed for quality assessment of AGHIs. The dataset comprises 4,000 images generated from 400 carefully crafted text prompts using 10 state of-the-art T2I models. We conduct a systematic subjective study to collect multidimensional annotations, including perceptual quality scores, text-image correspondence scores, visible and distorted body part labels. Based on AGHI-QA, we evaluate the strengths and weaknesses of current T2I methods in generating human images from multiple dimensions. Furthermore, we propose AGHI-Assessor, a novel quality metric that integrates the large multimodal model (LMM) with domain-specific human features for precise quality prediction and identification of visible and distorted body parts in AGHIs. Extensive experimental results demonstrate that AGHI-Assessor showcases state-of-the-art performance, significantly outperforming existing IQA methods in multidimensional quality assessment and surpassing leading LMMs in detecting structural distortions in AGHIs.

Medication reconciliation at clinical handoffs is a high-stakes, error-prone process. Large language models are increasingly proposed to assist with this task using FHIR-structured patient records, but a fundamental and largely unstudied variable is how the FHIR data is serialised before being passed to the model. We present the first systematic comparison of four FHIR serialisation strategies (Raw JSON, Markdown Table, Clinical Narrative, and Chronological Timeline) across five open-weight models (Phi-3.5-mini, Mistral-7B, BioMistral-7B, Llama-3.1-8B, Llama-3.3-70B) on a controlled benchmark of 200 synthetic patients, totalling 4,000 inference runs. We find that serialisation strategy has a large, statistically significant effect on performance for models up to 8B parameters: Clinical Narrative outperforms Raw JSON by up to 19 F1 points for Mistral-7B (r = 0.617, p < 10^{-10}). This advantage reverses at 70B, where Raw JSON achieves the best mean F1 of 0.9956. In all 20 model and strategy combinations, mean precision exceeds mean recall: omission is the dominant failure mode, with models more often missing an active medication than fabricating one, which changes how clinical safety auditing priorities should be set. Smaller models plateau at roughly 7-10 concurrent active medications, leaving polypharmacy patients, the patients most at risk from reconciliation errors, systematically underserved. BioMistral-7B, a domain-pretrained model without instruction tuning, produces zero usable output in all conditions, showing that domain pretraining alone is not sufficient for structured extraction. These results offer practical, evidence-based format recommendations for clinical LLM deployment: Clinical Narrative for models up to 8B, Raw JSON for 70B and above. The complete pipeline is reproducible on open-source tools running on an AWS g6e.xlarge instance (NVIDIA L40S, 48 GB VRAM).

Computed tomography and magnetic resonance imaging are two widely used clinical imaging modalities for non-invasive diagnosis. However, both of these modalities come with certain problems. CT uses harmful ionising radiation, and MRI suffers from slow acquisition speed. Both problems can be tackled by undersampling, such as sparse sampling. However, such undersampled data leads to lower resolution and introduces artefacts. Several techniques, including deep learning based methods, have been proposed to reconstruct such data. However, the undersampled reconstruction problem for these two modalities was always considered as two different problems and tackled separately by different research works. This paper proposes a unified solution for both sparse CT and undersampled radial MRI reconstruction, achieved by applying Fourier transform-based pre-processing on the radial MRI and then finally reconstructing both modalities using sinogram upsampling combined with filtered back-projection. The Primal-Dual network is a deep learning based method for reconstructing sparsely-sampled CT data. This paper introduces Primal-Dual UNet, which improves the Primal-Dual network in terms of accuracy and reconstruction speed. The proposed method resulted in an average SSIM of 0.932\textpm0.021 while performing sparse CT reconstruction for fan-beam geometry with a sparsity level of 16, achieving a statistically significant improvement over the previous model, which resulted in 0.919\textpm0.016. Furthermore, the proposed model resulted in 0.903\textpm0.019 and 0.957\textpm0.023 average SSIM while reconstructing undersampled brain and abdominal MRI data with an acceleration factor of 16, respectively - statistically significant improvements over the original model, which resulted in 0.867\textpm0.025 and 0.949\textpm0.025.

Previous work on augmenting large multimodal models (LMMs) for text-to-image (T2I) generation has focused on enriching the input space of in-context learning (ICL). This includes providing a few demonstrations and optimizing image descriptions to be more detailed and logical. However, as demand for more complex and flexible image descriptions grows, enhancing comprehension of input text within the ICL paradigm remains a critical yet underexplored area. In this work, we extend this line of research by constructing parallel multilingual prompts aimed at harnessing the multilingual capabilities of LMMs. More specifically, we translate the input text into several languages and provide the models with both the original text and the translations. Experiments on two LMMs across 3 benchmarks show that our method, PMT2I, achieves superior performance in general, compositional, and fine-grained assessments, especially in human preference alignment. Additionally, with its advantage of generating more diverse images, PMT2I significantly outperforms baseline prompts when incorporated with reranking methods. Our code and parallel multilingual data can be found at https://github.com/takagi97/PMT2I.

Brain atrophy and white matter hyperintensity (WMH) are critical neuroimaging features for ascertaining brain injury in cerebrovascular disease and multiple sclerosis. Automated segmentation and quantification is desirable but existing methods require high-resolution MRI with good signal-to-noise ratio (SNR). This precludes application to clinical and low-field portable MRI (pMRI) scans, thus hampering large-scale tracking of atrophy and WMH progression, especially in underserved areas where pMRI has huge potential. Here we present a method that segments white matter hyperintensity and 36 brain regions from scans of any resolution and contrast (including pMRI) without retraining. We show results on eight public datasets and on a private dataset with paired high- and low-field scans (3T and 64mT), where we attain strong correlation between the WMH (ρ=.85) and hippocampal volumes (r=.89) estimated at both fields. Our method is publicly available as part of FreeSurfer, at: http://surfer.nmr.mgh.harvard.edu/fswiki/WMH-SynthSeg.

Deep learning has shown strong performance in musculoskeletal imaging, but prior work has largely targeted conditions where diagnosis is relatively straightforward. More challenging problems remain underexplored, such as detecting Bankart lesions (anterior-inferior glenoid labral tears) on standard MRIs. These lesions are difficult to diagnose due to subtle imaging features, often necessitating invasive MRI arthrograms (MRAs). We introduce ScopeMRI, the first publicly available, expert-annotated dataset for shoulder pathologies, and present a deep learning framework for Bankart lesion detection on both standard MRIs and MRAs. ScopeMRI contains shoulder MRIs from patients who underwent arthroscopy, providing ground-truth labels from intraoperative findings, the diagnostic gold standard. Separate models were trained for MRIs and MRAs using CNN- and transformer-based architectures, with predictions ensembled across multiple imaging planes. Our models achieved radiologist-level performance, with accuracy on standard MRIs surpassing radiologists interpreting MRAs. External validation on independent hospital data demonstrated initial generalizability across imaging protocols. By releasing ScopeMRI and a modular codebase for training and evaluation, we aim to accelerate research in musculoskeletal imaging and foster development of datasets and models that address clinically challenging diagnostic tasks.

Multimodal Large Language Models (MLLMs) process visual, acoustic, and textual inputs, addressing the limitations of single-modality LLMs. However, existing benchmarks often overlook tri-modal evaluation in Traditional Chinese and do not consider inference latency. To address this, we introduce Multi-TW, the first Traditional Chinese benchmark for evaluating the performance and latency of any-to-any multimodal models. Multi-TW includes 900 multiple-choice questions (image and text, audio and text pairs) sourced from official proficiency tests developed with the Steering Committee for the Test of Proficiency-Huayu (SC-TOP). We evaluated various any-to-any models and vision-language models (VLMs) with audio transcription. Our results show that closed-source models generally outperform open-source ones across modalities, although open-source models can perform well in audio tasks. End-to-end any-to-any pipelines offer clear latency advantages compared to VLMs using separate audio transcription. Multi-TW presents a comprehensive view of model capabilities and highlights the need for Traditional Chinese fine-tuning and efficient multimodal architectures.

The rapid advancements of Text-to-Image (T2I) models have ushered in a new phase of AI-generated content, marked by their growing ability to interpret and follow user instructions. However, existing T2I model evaluation benchmarks fall short in limited prompt diversity and complexity, as well as coarse evaluation metrics, making it difficult to evaluate the fine-grained alignment performance between textual instructions and generated images. In this paper, we present TIIF-Bench (Text-to-Image Instruction Following Benchmark), aiming to systematically assess T2I models' ability in interpreting and following intricate textual instructions. TIIF-Bench comprises a set of 5000 prompts organized along multiple dimensions, which are categorized into three levels of difficulties and complexities. To rigorously evaluate model robustness to varying prompt lengths, we provide a short and a long version for each prompt with identical core semantics. Two critical attributes, i.e., text rendering and style control, are introduced to evaluate the precision of text synthesis and the aesthetic coherence of T2I models. In addition, we collect 100 high-quality designer level prompts that encompass various scenarios to comprehensively assess model performance. Leveraging the world knowledge encoded in large vision language models, we propose a novel computable framework to discern subtle variations in T2I model outputs. Through meticulous benchmarking of mainstream T2I models on TIIF-Bench, we analyze the pros and cons of current T2I models and reveal the limitations of current T2I benchmarks. Project Page: https://a113n-w3i.github.io/TIIF_Bench/.

MRI is an inherently slow process, which leads to long scan time for high-resolution imaging. The speed of acquisition can be increased by ignoring parts of the data (undersampling). Consequently, this leads to the degradation of image quality, such as loss of resolution or introduction of image artefacts. This work aims to reconstruct highly undersampled Cartesian or radial MR acquisitions, with better resolution and with less to no artefact compared to conventional techniques like compressed sensing. In recent times, deep learning has emerged as a very important area of research and has shown immense potential in solving inverse problems, e.g. MR image reconstruction. In this paper, a deep learning based MR image reconstruction framework is proposed, which includes a modified regularised version of ResNet as the network backbone to remove artefacts from the undersampled image, followed by data consistency steps that fusions the network output with the data already available from undersampled k-space in order to further improve reconstruction quality. The performance of this framework for various undersampling patterns has also been tested, and it has been observed that the framework is robust to deal with various sampling patterns, even when mixed together while training, and results in very high quality reconstruction, in terms of high SSIM (highest being 0.990pm0.006 for acceleration factor of 3.5), while being compared with the fully sampled reconstruction. It has been shown that the proposed framework can successfully reconstruct even for an acceleration factor of 20 for Cartesian (0.968pm0.005) and 17 for radially (0.962pm0.012) sampled data. Furthermore, it has been shown that the framework preserves brain pathology during reconstruction while being trained on healthy subjects.

Large Language Models (LLMs) have demonstrated a remarkable potential in medical knowledge acquisition and question-answering. However, LLMs can potentially hallucinate and yield factually incorrect outcomes, even with domain-specific pretraining. Previously, retrieval augmented generation (RAG) has limited success in addressing hallucinations. Unlike previous methods in RAG where the retrieval model was trained separately from the LLM, we introduce JMLR (for Jointly trains LLM and information Retrieval) during the fine-tuning phase. The synchronized training mechanism enhances JMLR's ability to retrieve clinical guidelines and leverage medical knowledge to reason and answer questions and reduces the demand for computational resources. We evaluated JMLR on the important medical question-answering application. Our experimental results demonstrate that JMLR-13B (70.5%) outperforms a previous state-of-the-art open-source model using conventional pre-training and fine-tuning Meditron-70B (68.9%) and Llama2-13B with RAG (67.7%) on a medical question-answering dataset. Comprehensive evaluations reveal JMLR-13B enhances reasoning quality and reduces hallucinations better than Claude3-Opus. Additionally, JMLR-13B (148 GPU hours) also trains much faster than Meditron-70B (42630 GPU hours). Through this work, we provide a new and efficient knowledge enhancement method for healthcare, demonstrating the potential of integrating retrieval and LLM training for medical question-answering systems.

Multimodal retrieval systems are becoming increasingly vital for cutting-edge AI technologies, such as embodied AI and AI-driven digital content industries. However, current multimodal retrieval tasks lack sufficient complexity and demonstrate limited practical application value. It spires us to design Instance-Driven Multimodal Image Retrieval (IDMR), a novel task that requires models to retrieve images containing the same instance as a query image while matching a text-described scenario. Unlike existing retrieval tasks focused on global image similarity or category-level matching, IDMR demands fine-grained instance-level consistency across diverse contexts. To benchmark this capability, we develop IDMR-bench using real-world object tracking and first-person video data. Addressing the scarcity of training data, we propose a cross-domain synthesis method that creates 557K training samples by cropping objects from standard detection datasets. Our Multimodal Large Language Model (MLLM) based retrieval model, trained on 1.2M samples, outperforms state-of-the-art approaches on both traditional benchmarks and our zero-shot IDMR-bench. Experimental results demonstrate previous models' limitations in instance-aware retrieval and highlight the potential of MLLM for advanced retrieval applications. The whole training dataset, codes and models, with wide ranges of sizes, are available at https://github.com/BwLiu01/IDMR.

Medical information retrieval (MIR) is essential for retrieving relevant medical knowledge from diverse sources, including electronic health records, scientific literature, and medical databases. However, achieving effective zero-shot dense retrieval in the medical domain poses substantial challenges due to the lack of relevance-labeled data. In this paper, we introduce a novel approach called Self-Learning Hypothetical Document Embeddings (SL-HyDE) to tackle this issue. SL-HyDE leverages large language models (LLMs) as generators to generate hypothetical documents based on a given query. These generated documents encapsulate key medical context, guiding a dense retriever in identifying the most relevant documents. The self-learning framework progressively refines both pseudo-document generation and retrieval, utilizing unlabeled medical corpora without requiring any relevance-labeled data. Additionally, we present the Chinese Medical Information Retrieval Benchmark (CMIRB), a comprehensive evaluation framework grounded in real-world medical scenarios, encompassing five tasks and ten datasets. By benchmarking ten models on CMIRB, we establish a rigorous standard for evaluating medical information retrieval systems. Experimental results demonstrate that SL-HyDE significantly surpasses existing methods in retrieval accuracy while showcasing strong generalization and scalability across various LLM and retriever configurations. CMIRB data and evaluation code are publicly available at: https://github.com/CMIRB-benchmark/CMIRB.

In this paper, we present TMR, a simple yet effective approach for text to 3D human motion retrieval. While previous work has only treated retrieval as a proxy evaluation metric, we tackle it as a standalone task. Our method extends the state-of-the-art text-to-motion synthesis model TEMOS, and incorporates a contrastive loss to better structure the cross-modal latent space. We show that maintaining the motion generation loss, along with the contrastive training, is crucial to obtain good performance. We introduce a benchmark for evaluation and provide an in-depth analysis by reporting results on several protocols. Our extensive experiments on the KIT-ML and HumanML3D datasets show that TMR outperforms the prior work by a significant margin, for example reducing the median rank from 54 to 19. Finally, we showcase the potential of our approach on moment retrieval. Our code and models are publicly available at https://mathis.petrovich.fr/tmr.

Multimodal Large Language Models (MLLMs) increasingly excel at perception, understanding, and reasoning. However, current benchmarks inadequately evaluate their ability to perform these tasks continuously in dynamic, real-world environments. To bridge this gap, we introduce RTV-Bench, a fine-grained benchmark for MLLM real-time video analysis. RTV-Bench uses three key principles: (1) Multi-Timestamp Question Answering (MTQA), where answers evolve with scene changes; (2) Hierarchical Question Structure, combining basic and advanced queries; and (3) Multi-dimensional Evaluation, assessing the ability of continuous perception, understanding, and reasoning. RTV-Bench contains 552 diverse videos (167.2 hours) and 4,631 high-quality QA pairs. We evaluated leading MLLMs, including proprietary (GPT-4o, Gemini 2.0), open-source offline (Qwen2.5-VL, VideoLLaMA3), and open-source real-time (VITA-1.5, InternLM-XComposer2.5-OmniLive) models. Experiment results show open-source real-time models largely outperform offline ones but still trail top proprietary models. Our analysis also reveals that larger model size or higher frame sampling rates do not significantly boost RTV-Bench performance, sometimes causing slight decreases. This underscores the need for better model architectures optimized for video stream processing and long sequences to advance real-time video analysis with MLLMs. Our benchmark toolkit is available at: https://github.com/LJungang/RTV-Bench.

We introduce MRMR, the first expert-level multidisciplinary multimodal retrieval benchmark requiring intensive reasoning. MRMR contains 1,502 queries spanning 23 domains, with positive documents carefully verified by human experts. Compared to prior benchmarks, MRMR introduces three key advancements. First, it challenges retrieval systems across diverse areas of expertise, enabling fine-grained model comparison across domains. Second, queries are reasoning-intensive, with images requiring deeper interpretation such as diagnosing microscopic slides. We further introduce Contradiction Retrieval, a novel task requiring models to identify conflicting concepts. Finally, queries and documents are constructed as image-text interleaved sequences. Unlike earlier benchmarks restricted to single images or unimodal documents, MRMR offers a realistic setting with multi-image queries and mixed-modality corpus documents. We conduct an extensive evaluation of 4 categories of multimodal retrieval systems and 14 frontier models on MRMR. The text embedding model Qwen3-Embedding with LLM-generated image captions achieves the highest performance, highlighting substantial room for improving multimodal retrieval models. Although latest multimodal models such as Ops-MM-Embedding perform competitively on expert-domain queries, they fall short on reasoning-intensive tasks. We believe that MRMR paves the way for advancing multimodal retrieval in more realistic and challenging scenarios.

It is highly desired but challenging to acquire high-quality photos with clear content in low-light environments. Although multi-image processing methods (using burst, dual-exposure, or multi-exposure images) have made significant progress in addressing this issue, they typically focus on specific restoration or enhancement problems, and do not fully explore the potential of utilizing multiple images. Motivated by the fact that multi-exposure images are complementary in denoising, deblurring, high dynamic range imaging, and super-resolution, we propose to utilize exposure bracketing photography to get a high-quality image by combining these tasks in this work. Due to the difficulty in collecting real-world pairs, we suggest a solution that first pre-trains the model with synthetic paired data and then adapts it to real-world unlabeled images. In particular, a temporally modulated recurrent network (TMRNet) and self-supervised adaptation method are proposed. Moreover, we construct a data simulation pipeline to synthesize pairs and collect real-world images from 200 nighttime scenarios. Experiments on both datasets show that our method performs favorably against the state-of-the-art multi-image processing ones. Code and datasets are available at https://github.com/cszhilu1998/BracketIRE.

Neural retrieval methods using transformer-based pre-trained language models have advanced multilingual and cross-lingual retrieval. However, their effectiveness for low-resource, morphologically rich languages such as Amharic remains underexplored due to data scarcity and suboptimal tokenization. We address this gap by introducing Amharic-specific dense retrieval models based on pre-trained Amharic BERT and RoBERTa backbones. Our proposed RoBERTa-Base-Amharic-Embed model (110M parameters) achieves a 17.6% relative improvement in MRR@10 and a 9.86% gain in Recall@10 over the strongest multilingual baseline, Arctic Embed 2.0 (568M parameters). More compact variants, such as RoBERTa-Medium-Amharic-Embed (42M), remain competitive while being over 13x smaller. Additionally, we train a ColBERT-based late interaction retrieval model that achieves the highest MRR@10 score (0.843) among all evaluated models. We benchmark our proposed models against both sparse and dense retrieval baselines to systematically assess retrieval effectiveness in Amharic. Our analysis highlights key challenges in low-resource settings and underscores the importance of language-specific adaptation. To foster future research in low-resource IR, we publicly release our dataset, codebase, and trained models at https://github.com/kidist-amde/amharic-ir-benchmarks.

RAW files are the initial measurement of scene radiance widely used in most cameras, and the ubiquitously-used RGB images are converted from RAW data through Image Signal Processing (ISP) pipelines. Nowadays, digital images are risky of being nefariously manipulated. Inspired by the fact that innate immunity is the first line of body defense, we propose DRAW, a novel scheme of defending images against manipulation by protecting their sources, i.e., camera-shooted RAWs. Specifically, we design a lightweight Multi-frequency Partial Fusion Network (MPF-Net) friendly to devices with limited computing resources by frequency learning and partial feature fusion. It introduces invisible watermarks as protective signal into the RAW data. The protection capability can not only be transferred into the rendered RGB images regardless of the applied ISP pipeline, but also is resilient to post-processing operations such as blurring or compression. Once the image is manipulated, we can accurately identify the forged areas with a localization network. Extensive experiments on several famous RAW datasets, e.g., RAISE, FiveK and SIDD, indicate the effectiveness of our method. We hope that this technique can be used in future cameras as an option for image protection, which could effectively restrict image manipulation at the source.

We introduce MedMNIST v2, a large-scale MNIST-like dataset collection of standardized biomedical images, including 12 datasets for 2D and 6 datasets for 3D. All images are pre-processed into a small size of 28x28 (2D) or 28x28x28 (3D) with the corresponding classification labels so that no background knowledge is required for users. Covering primary data modalities in biomedical images, MedMNIST v2 is designed to perform classification on lightweight 2D and 3D images with various dataset scales (from 100 to 100,000) and diverse tasks (binary/multi-class, ordinal regression, and multi-label). The resulting dataset, consisting of 708,069 2D images and 10,214 3D images in total, could support numerous research / educational purposes in biomedical image analysis, computer vision, and machine learning. We benchmark several baseline methods on MedMNIST v2, including 2D / 3D neural networks and open-source / commercial AutoML tools. The data and code are publicly available at https://medmnist.com/.

Aligning Text-to-Image (T2I) generation models with human preferences increasingly relies on image reward models that score or rank generated images according to prompt alignment and perceptual quality. Existing reward models are commonly trained as Bradley-Terry (BT) preference models on large-scale human preference corpora, making them costly to train, difficult to adapt, and opaque in their evaluation criteria. Meanwhile, Vision-Language Model (VLM) judges can provide more fine-grained assessments through textual rubrics, but their manually designed or heuristically generated scoring rules may fail to reliably reflect human preferences. In this paper, we propose AutoRubric-T2I, the first rubric learning framework in T2I that automatically synthesizes and selects explicit rubrics for guiding VLM judges. AutoRubric-T2I first synthesizes reasoning traces from preference pairs into candidate rubrics, then uses a VLM judge to score paired images under each rubric, producing pairwise rubric-score differences for preference learning. To remove noisy and redundant rules, we further employ a ell_1-Regularized Logistic Regression Refiner, which selects the Top-N most discriminative rubrics. Extensive evaluations show that AutoRubric-T2I produces high-quality, interpretable reward signals using less than 0.01% of the annotated preference data, substantially reducing the need for large-scale reward-model training. On image reward benchmarks such as MMRB2, AutoRubric-T2I outperforms strong reward model baselines. We further validate AutoRubric-T2I as an RL reward on downstream T2I tasks, including TIIF and UniGenBench++, where it improves generation quality over scalar reward models using the Flow-GRPO pipeline on diffusion models.

Magnetic Resonance Imaging (MRI) is a critical tool in modern medical diagnostics, yet its prolonged acquisition time remains a critical limitation, especially in time-sensitive clinical scenarios. While undersampling strategies can accelerate image acquisition, they often result in image artifacts and degraded quality. Recent diffusion models have shown promise for reconstructing high-fidelity images from undersampled data by learning powerful image priors; however, most existing approaches either (i) rely on unsupervised score functions without paired supervision or (ii) apply data consistency only as a post-processing step. In this work, we introduce a conditional denoising diffusion framework with iterative data-consistency correction, which differs from prior methods by embedding the measurement model directly into every reverse diffusion step and training the model on paired undersampled-ground truth data. This hybrid design bridges generative flexibility with explicit enforcement of MRI physics. Experiments on the fastMRI dataset demonstrate that our framework consistently outperforms recent state-of-the-art deep learning and diffusion-based methods in SSIM, PSNR, and LPIPS, with LPIPS capturing perceptual improvements more faithfully. These results demonstrate that integrating conditional supervision with iterative consistency updates yields substantial improvements in both pixel-level fidelity and perceptual realism, establishing a principled and practical advance toward robust, accelerated MRI reconstruction.

Hospitals in India still rely on handwritten medical records despite the availability of Electronic Medical Records (EMR), complicating statistical analysis and record retrieval. Handwritten records pose a unique challenge, requiring specialized data for training models to recognize medications and their recommendation patterns. While traditional handwriting recognition approaches employ 2-D LSTMs, recent studies have explored using Multimodal Large Language Models (MLLMs) for OCR tasks. Building on this approach, we focus on extracting medication names and dosages from simulated medical records. Our methodology MIRAGE (Multimodal Identification and Recognition of Annotations in indian GEneral prescriptions) involves fine-tuning the QWEN VL, LLaVA 1.6 and Idefics2 models on 743,118 high resolution simulated medical record images-fully annotated from 1,133 doctors across India. Our approach achieves 82% accuracy in extracting medication names and dosages.

RAW images preserve superior fidelity and rich scene information compared to RGB, making them essential for tasks in challenging imaging conditions. To alleviate the high cost of data collection, recent RGB-to-RAW conversion methods aim to synthesize RAW images from RGB. However, they overlook two key challenges: (i) the reconstruction difficulty varies with pixel intensity, and (ii) multi-camera conversion requires camera-specific adaptation. To address these issues, we propose SpiralDiff, a diffusion-based framework tailored for RGB-to-RAW conversion with a signal-dependent noise weighting strategy that adapts reconstruction fidelity across intensity levels. In addition, we introduce CamLoRA, a camera-aware lightweight adaptation module that enables a unified model to adapt to different camera-specific ISP characteristics. Extensive experiments on four benchmark datasets demonstrate the superiority of SpiralDiff in RGB-to-RAW conversion quality and its downstream benefits in RAW-based object detection. Our code and model are available at https://github.com/Chuancy-TJU/SpiralDiff.

Compressed Sensing MRI reconstructs images of the body's internal anatomy from undersampled measurements, thereby reducing scan time. Recently, deep learning has shown great potential for reconstructing high-fidelity images from highly undersampled measurements. However, one needs to train multiple models for different undersampling patterns and desired output image resolutions, since most networks operate on a fixed discretization. Such approaches are highly impractical in clinical settings, where undersampling patterns and image resolutions are frequently changed to accommodate different real-time imaging and diagnostic requirements. We propose a unified MRI reconstruction model robust to various measurement undersampling patterns and image resolutions. Our approach uses neural operators, a discretization-agnostic architecture applied in both image and measurement spaces, to capture local and global features. Empirically, our model improves SSIM by 11% and PSNR by 4 dB over a state-of-the-art CNN (End-to-End VarNet), with 600times faster inference than diffusion methods. The resolution-agnostic design also enables zero-shot super-resolution and extended field-of-view reconstruction, offering a versatile and efficient solution for clinical MR imaging. Our unified model offers a versatile solution for MRI, adapting seamlessly to various measurement undersampling and imaging resolutions, making it highly effective for flexible and reliable clinical imaging. Our code is available at https://armeet.ca/nomri.

The potential of Multimodal Large Language Models (MLLMs) in domain of medical imaging raise the demands of systematic and rigorous evaluation frameworks that are aligned with the real-world medical imaging practice. Existing practices that report single or coarse-grained metrics are lack the granularity required for specialized clinical support and fail to assess the reliability of reasoning mechanisms. To address this, we propose a paradigm shift toward multidimensional, fine-grained and in-depth evaluation. Based on a two-stage systematic construction pipeline designed for this paradigm, we instantiate it with MedRCube. We benchmark 33 MLLMs, Lingshu-32B achieve top-tier performance. Crucially, MedRCube exposes a series of pronounced insights inaccessible under prior evaluation settings. Furthermore, we introduce a credibility evaluation subset to quantify reasoning credibility, uncover a highly significant positive association between shortcut behavior and diagnostic task performance, raising concerns for clinically trustworthy deployment. The resources of this work can be found at https://github.com/F1mc/MedRCube.

The integration of neural-network-based systems into clinical practice is limited by challenges related to domain generalization and robustness. The computer vision community established benchmarks such as ImageNet-C as a fundamental prerequisite to measure progress towards those challenges. Similar datasets are largely absent in the medical imaging community which lacks a comprehensive benchmark that spans across imaging modalities and applications. To address this gap, we create and open-source MedMNIST-C, a benchmark dataset based on the MedMNIST+ collection covering 12 datasets and 9 imaging modalities. We simulate task and modality-specific image corruptions of varying severity to comprehensively evaluate the robustness of established algorithms against real-world artifacts and distribution shifts. We further provide quantitative evidence that our simple-to-use artificial corruptions allow for highly performant, lightweight data augmentation to enhance model robustness. Unlike traditional, generic augmentation strategies, our approach leverages domain knowledge, exhibiting significantly higher robustness when compared to widely adopted methods. By introducing MedMNIST-C and open-sourcing the corresponding library allowing for targeted data augmentations, we contribute to the development of increasingly robust methods tailored to the challenges of medical imaging. The code is available at https://github.com/francescodisalvo05/medmnistc-api .

Real-time recurrent learning (RTRL) for sequence-processing recurrent neural networks (RNNs) offers certain conceptual advantages over backpropagation through time (BPTT). RTRL requires neither caching past activations nor truncating context, and enables online learning. However, RTRL's time and space complexity make it impractical. To overcome this problem, most recent work on RTRL focuses on approximation theories, while experiments are often limited to diagnostic settings. Here we explore the practical promise of RTRL in more realistic settings. We study actor-critic methods that combine RTRL and policy gradients, and test them in several subsets of DMLab-30, ProcGen, and Atari-2600 environments. On DMLab memory tasks, our system trained on fewer than 1.2 B environmental frames is competitive with or outperforms well-known IMPALA and R2D2 baselines trained on 10 B frames. To scale to such challenging tasks, we focus on certain well-known neural architectures with element-wise recurrence, allowing for tractable RTRL without approximation. Importantly, we also discuss rarely addressed limitations of RTRL in real-world applications, such as its complexity in the multi-layer case.

Most recent real-world image super-resolution (Real-ISR) methods employ pre-trained text-to-image (T2I) diffusion models to synthesize the high-quality image either from random Gaussian noise, which yields realistic results but is slow due to iterative denoising, or directly from the input low-quality image, which is efficient but at the price of lower output quality. These approaches train ControlNet or LoRA modules while keeping the pre-trained model fixed, which often introduces over-enhanced artifacts and hallucinations, suffering from the robustness to inputs of varying degradations. Recent visual autoregressive (AR) models, such as pre-trained Infinity, can provide strong T2I generation capabilities while offering superior efficiency by using the bitwise next-scale prediction strategy. Building upon next-scale prediction, we introduce a robust Real-ISR framework, namely Next-Scale Autoregressive Modeling (NSARM). Specifically, we train NSARM in two stages: a transformation network is first trained to map the input low-quality image to preliminary scales, followed by an end-to-end full-model fine-tuning. Such a comprehensive fine-tuning enhances the robustness of NSARM in Real-ISR tasks without compromising its generative capability. Extensive quantitative and qualitative evaluations demonstrate that as a pure AR model, NSARM achieves superior visual results over existing Real-ISR methods while maintaining a fast inference speed. Most importantly, it demonstrates much higher robustness to the quality of input images, showing stronger generalization performance. Project page: https://github.com/Xiangtaokong/NSARM

Typical quantitative MRI (qMRI) methods estimate parameter maps after image reconstructing, which is prone to biases and error propagation. We propose a Nonlinear Conjugate Gradient (NLCG) optimizer for model-based T2/T1 estimation, which incorporates U-Net regularization trained in a scan-specific manner. This end-to-end method directly estimates qMRI maps from undersampled k-space data using mono-exponential signal modeling with zero-shot scan-specific neural network regularization to enable high fidelity T1 and T2 mapping. T2 and T1 mapping results demonstrate the ability of the proposed NLCG-Net to improve estimation quality compared to subspace reconstruction at high accelerations.

Real-world image super-resolution (Real-ISR) aims at restoring high-quality (HQ) images from low-quality (LQ) inputs corrupted by unknown and complex degradations. In particular, pretrained text-to-image (T2I) diffusion models provide strong generative priors to reconstruct credible and intricate details. However, T2I generation focuses on semantic consistency while Real-ISR emphasizes pixel-level reconstruction, which hinders existing methods from fully exploiting diffusion priors. To address this challenge, we introduce ConsisSR to handle both semantic and pixel-level consistency. Specifically, compared to coarse-grained text prompts, we exploit the more powerful CLIP image embedding and effectively leverage both modalities through our Hybrid Prompt Adapter (HPA) for semantic guidance. Secondly, we introduce Time-aware Latent Augmentation (TALA) to mitigate the inherent gap between T2I generation and Real-ISR consistency requirements. By randomly mixing LQ and HQ latent inputs, our model not only handle timestep-specific diffusion noise but also refine the accumulated latent representations. Last but not least, our GAN-Embedding strategy employs the pretrained Real-ESRGAN model to refine the diffusion start point. This accelerates the inference process to 10 steps while preserving sampling quality, in a training-free manner. Our method demonstrates state-of-the-art performance among both full-scale and accelerated models. The code will be made publicly available.

Positron emission tomography (PET) is a cornerstone of modern oncologic and neurologic imaging, distinguished by its unique ability to illuminate dynamic metabolic processes that transcend the anatomical focus of traditional imaging technologies. Radiology reports are essential for clinical decision making, yet their manual creation is labor-intensive and time-consuming. Recent advancements of vision-language models (VLMs) have shown strong potential in medical applications, presenting a promising avenue for automating report generation. However, existing applications of VLMs in the medical domain have predominantly focused on structural imaging modalities, while the unique characteristics of molecular PET imaging have largely been overlooked. To bridge the gap, we introduce PET2Rep, a large-scale comprehensive benchmark for evaluation of general and medical VLMs for radiology report generation for PET images. PET2Rep stands out as the first dedicated dataset for PET report generation with metabolic information, uniquely capturing whole-body image-report pairs that cover dozens of organs to fill the critical gap in existing benchmarks and mirror real-world clinical comprehensiveness. In addition to widely recognized natural language generation metrics, we introduce a series of clinical efficiency metrics to evaluate the quality of radiotracer uptake pattern description in key organs in generated reports. We conduct a head-to-head comparison of 30 cutting-edge general-purpose and medical-specialized VLMs. The results show that the current state-of-the-art VLMs perform poorly on PET report generation task, falling considerably short of fulfilling practical needs. Moreover, we identify several key insufficiency that need to be addressed to advance the development in medical applications.

Clinical routine and retrospective cohorts commonly include multi-parametric Magnetic Resonance Imaging; however, they are mostly acquired in different anisotropic 2D views due to signal-to-noise-ratio and scan-time constraints. Thus acquired views suffer from poor out-of-plane resolution and affect downstream volumetric image analysis that typically requires isotropic 3D scans. Combining different views of multi-contrast scans into high-resolution isotropic 3D scans is challenging due to the lack of a large training cohort, which calls for a subject-specific framework. This work proposes a novel solution to this problem leveraging Implicit Neural Representations (INR). Our proposed INR jointly learns two different contrasts of complementary views in a continuous spatial function and benefits from exchanging anatomical information between them. Trained within minutes on a single commodity GPU, our model provides realistic super-resolution across different pairs of contrasts in our experiments with three datasets. Using Mutual Information (MI) as a metric, we find that our model converges to an optimum MI amongst sequences, achieving anatomically faithful reconstruction. Code is available at: https://github.com/jqmcginnis/multi_contrast_inr/

We present GoLongRL, a fully open-source, capability-oriented post-training recipe for long-context reinforcement learning with verifiable rewards (RLVR). Existing long-context RL methods often treat data construction as a matter of designing increasingly complex retrieval paths, leading to homogeneous task coverage and reward formulations that inadequately reflect practical long-context requirements. Our work offers two contributions. (1) Capability-oriented data construction with full open release. We openly release a dataset of 23K RLVR samples, the complete construction pipeline, and all training code. Guided by a taxonomy of long-context capabilities, the dataset spans 9 task types, each paired with its natural evaluation metric. It comprises curated open-source samples from established corpora and synthetic samples whose QA pairs are generated from real source documents such as books, academic papers, and multi-turn dialogues. Under the same vanilla GRPO setup, our dataset alone outperforms the closed-source QwenLong-L1.5 dataset. Moreover, our Qwen3-30B-A3B model trained on this data delivers long-context performance comparable to DeepSeek-R1-0528 and Qwen3-235B-A22B-Thinking-2507, suggesting that broader coverage and greater reward diversity substantially benefit long-context capability improvement. (2) TMN-Reweight for heterogeneous multitask optimization. To address optimization challenges from heterogeneous rewards, we propose TMN-Reweight, which combines task-level mean normalization for cross-task reward scale alignment with difficulty-adaptive weighting for more reliable advantage estimation. TMN-Reweight further improves average performance over vanilla GRPO, with general capabilities preserved or improved across reported evaluations.

Text-to-image (T2I) models have rapidly advanced, enabling the generation of high-quality images from text prompts across various domains. However, these models present notable safety concerns, including the risk of generating harmful, biased, or private content. Current research on assessing T2I safety remains in its early stages. While some efforts have been made to evaluate models on specific safety dimensions, many critical risks remain unexplored. To address this gap, we introduce T2ISafety, a safety benchmark that evaluates T2I models across three key domains: toxicity, fairness, and bias. We build a detailed hierarchy of 12 tasks and 44 categories based on these three domains, and meticulously collect 70K corresponding prompts. Based on this taxonomy and prompt set, we build a large-scale T2I dataset with 68K manually annotated images and train an evaluator capable of detecting critical risks that previous work has failed to identify, including risks that even ultra-large proprietary models like GPTs cannot correctly detect. We evaluate 12 prominent diffusion models on T2ISafety and reveal several concerns including persistent issues with racial fairness, a tendency to generate toxic content, and significant variation in privacy protection across the models, even with defense methods like concept erasing. Data and evaluator are released under https://github.com/adwardlee/t2i_safety.

We introduce TransDiff, the first image generation model that marries Autoregressive (AR) Transformer with diffusion models. In this joint modeling framework, TransDiff encodes labels and images into high-level semantic features and employs a diffusion model to estimate the distribution of image samples. On the ImageNet 256x256 benchmark, TransDiff significantly outperforms other image generation models based on standalone AR Transformer or diffusion models. Specifically, TransDiff achieves a Fr\'echet Inception Distance (FID) of 1.61 and an Inception Score (IS) of 293.4, and further provides x2 faster inference latency compared to state-of-the-art methods based on AR Transformer and x112 faster inference compared to diffusion-only models. Furthermore, building on the TransDiff model, we introduce a novel image generation paradigm called Multi-Reference Autoregression (MRAR), which performs autoregressive generation by predicting the next image. MRAR enables the model to reference multiple previously generated images, thereby facilitating the learning of more diverse representations and improving the quality of generated images in subsequent iterations. By applying MRAR, the performance of TransDiff is improved, with the FID reduced from 1.61 to 1.42. We expect TransDiff to open up a new frontier in the field of image generation.

Clinical decision-making in radiology increasingly benefits from artificial intelligence (AI), particularly through large language models (LLMs). However, traditional retrieval-augmented generation (RAG) systems for radiology question answering (QA) typically rely on single-step retrieval, limiting their ability to handle complex clinical reasoning tasks. Here we propose radiology Retrieval and Reasoning (RaR), a multi-step retrieval and reasoning framework designed to improve diagnostic accuracy, factual consistency, and clinical reliability of LLMs in radiology question answering. We evaluated 25 LLMs spanning diverse architectures, parameter scales (0.5B to >670B), and training paradigms (general-purpose, reasoning-optimized, clinically fine-tuned), using 104 expert-curated radiology questions from previously established RSNA-RadioQA and ExtendedQA datasets. To assess generalizability, we additionally tested on an unseen internal dataset of 65 real-world radiology board examination questions. RaR significantly improved mean diagnostic accuracy over zero-shot prompting and conventional online RAG. The greatest gains occurred in small-scale models, while very large models (>200B parameters) demonstrated minimal changes (<2% improvement). Additionally, RaR retrieval reduced hallucinations (mean 9.4%) and retrieved clinically relevant context in 46% of cases, substantially aiding factual grounding. Even clinically fine-tuned models showed gains from RaR (e.g., MedGemma-27B), indicating that retrieval remains beneficial despite embedded domain knowledge. These results highlight the potential of RaR to enhance factuality and diagnostic accuracy in radiology QA, warranting future studies to validate their clinical utility. All datasets, code, and the full RaR framework are publicly available to support open research and clinical translation.

This paper reports on the NTIRE 2025 XGC Quality Assessment Challenge, which will be held in conjunction with the New Trends in Image Restoration and Enhancement Workshop (NTIRE) at CVPR 2025. This challenge is to address a major challenge in the field of video and talking head processing. The challenge is divided into three tracks, including user generated video, AI generated video and talking head. The user-generated video track uses the FineVD-GC, which contains 6,284 user generated videos. The user-generated video track has a total of 125 registered participants. A total of 242 submissions are received in the development phase, and 136 submissions are received in the test phase. Finally, 5 participating teams submitted their models and fact sheets. The AI generated video track uses the Q-Eval-Video, which contains 34,029 AI-Generated Videos (AIGVs) generated by 11 popular Text-to-Video (T2V) models. A total of 133 participants have registered in this track. A total of 396 submissions are received in the development phase, and 226 submissions are received in the test phase. Finally, 6 participating teams submitted their models and fact sheets. The talking head track uses the THQA-NTIRE, which contains 12,247 2D and 3D talking heads. A total of 89 participants have registered in this track. A total of 225 submissions are received in the development phase, and 118 submissions are received in the test phase. Finally, 8 participating teams submitted their models and fact sheets. Each participating team in every track has proposed a method that outperforms the baseline, which has contributed to the development of fields in three tracks.

Composed Image Retrieval (CIR) involves retrieving a target image based on a composed query of an image paired with text that specifies modifications or changes to the visual reference. CIR is inherently an instruction-following task, as the model needs to interpret and apply modifications to the image. In practice, due to the scarcity of annotated data in downstream tasks, Zero-Shot CIR (ZS-CIR) is desirable. While existing ZS-CIR models based on CLIP have shown promising results, their capability in interpreting and following modification instructions remains limited. Some research attempts to address this by incorporating Large Language Models (LLMs). However, these approaches still face challenges in effectively integrating multimodal information and instruction understanding. To tackle above challenges, we propose a novel embedding method utilizing an instruction-tuned Multimodal LLM (MLLM) to generate composed representation, which significantly enhance the instruction following capability for a comprehensive integration between images and instructions. Nevertheless, directly applying MLLMs introduces a new challenge since MLLMs are primarily designed for text generation rather than embedding extraction as required in CIR. To address this, we introduce a two-stage training strategy to efficiently learn a joint multimodal embedding space and further refining the ability to follow modification instructions by tuning the model in a triplet dataset similar to the CIR format. Extensive experiments on four public datasets: FashionIQ, CIRR, GeneCIS, and CIRCO demonstrates the superior performance of our model, outperforming state-of-the-art baselines by a significant margin. Codes are available at the GitHub repository.

Multimodal Large Language Models (MLLMs) have achieved considerable accuracy in Optical Character Recognition (OCR) from static images. However, their efficacy in video OCR is significantly diminished due to factors such as motion blur, temporal variations, and visual effects inherent in video content. To provide clearer guidance for training practical MLLMs, we introduce the MME-VideoOCR benchmark, which encompasses a comprehensive range of video OCR application scenarios. MME-VideoOCR features 10 task categories comprising 25 individual tasks and spans 44 diverse scenarios. These tasks extend beyond text recognition to incorporate deeper comprehension and reasoning of textual content within videos. The benchmark consists of 1,464 videos with varying resolutions, aspect ratios, and durations, along with 2,000 meticulously curated, manually annotated question-answer pairs. We evaluate 18 state-of-the-art MLLMs on MME-VideoOCR, revealing that even the best-performing model (Gemini-2.5 Pro) achieves an accuracy of only 73.7%. Fine-grained analysis indicates that while existing MLLMs demonstrate strong performance on tasks where relevant texts are contained within a single or few frames, they exhibit limited capability in effectively handling tasks that demand holistic video comprehension. These limitations are especially evident in scenarios that require spatio-temporal reasoning, cross-frame information integration, or resistance to language prior bias. Our findings also highlight the importance of high-resolution visual input and sufficient temporal coverage for reliable OCR in dynamic video scenarios.

Extraction of relevant pathological terms from radiology reports is important for correct image label generation and disease population studies. In this letter, we compare the performance of some known application program interface (APIs) for the task of thoracic abnormality extraction from radiology reports. We explored several medical domain specific annotation tools like Medical Text Indexer(MTI) with Non-MEDLINE and Mesh On Demand(MOD) options and generic Natural Language Understanding (NLU) API provided by the IBM cloud. Our results show that although MTI and MOD are intended for extracting medical terms, their performance is worst compared to generic extraction API like IBM NLU. Finally, we trained a DNN-based Named Entity Recognition (NER) model to extract the key concept words from radiology reports. Our model outperforms the medical specific and generic API performance by a large margin. Our results demonstrate the inadequacy of generic APIs for pathology extraction task and establish the importance of domain specific model training for improved results. We hope that these results motivate the research community to release larger de-identified radiology reports corpus for building high accuracy machine learning models for the important task of pathology extraction.

sRGB images are now the predominant choice for pre-training visual models in computer vision research, owing to their ease of acquisition and efficient storage. Meanwhile, the advantage of RAW images lies in their rich physical information under variable real-world challenging lighting conditions. For computer vision tasks directly based on camera RAW data, most existing studies adopt methods of integrating image signal processor (ISP) with backend networks, yet often overlook the interaction capabilities between the ISP stages and subsequent networks. Drawing inspiration from ongoing adapter research in NLP and CV areas, we introduce RAW-Adapter, a novel approach aimed at adapting sRGB pre-trained models to camera RAW data. RAW-Adapter comprises input-level adapters that employ learnable ISP stages to adjust RAW inputs, as well as model-level adapters to build connections between ISP stages and subsequent high-level networks. Additionally, RAW-Adapter is a general framework that could be used in various computer vision frameworks. Abundant experiments under different lighting conditions have shown our algorithm's state-of-the-art (SOTA) performance, demonstrating its effectiveness and efficiency across a range of real-world and synthetic datasets.

In this work, we propose Image-to-Image Rectified Flow Reformulation (I2I-RFR), a practical plug-in reformulation that recasts standard I2I regression networks as continuous-time transport models. While pixel-wise I2I regression is simple, stable, and easy to adapt across tasks, it often over-smooths ill-posed and multimodal targets, whereas generative alternatives often require additional components, task-specific tuning, and more complex training and inference pipelines. Our method augments the backbone input by channel-wise concatenation with a noise-corrupted version of the ground-truth target and optimizes a simple t-reweighted pixel loss. This objective admits a rectified-flow interpretation via an induced velocity field, enabling ODE-based progressive refinement at inference time while largely preserving the standard supervised training pipeline. In most cases, adopting I2I-RFR requires only expanding the input channels, and inference can be performed with a few explicit solver steps (e.g., 3 steps) without distillation. Extensive experiments across multiple image-to-image translation and video restoration tasks show that I2I-RFR generally improves performance across a wide range of tasks and backbones, with particularly clear gains in perceptual quality and detail preservation. Overall, I2I-RFR provides a lightweight way to incorporate continuous-time refinement into conventional I2I models without requiring a heavy generative pipeline.

Text-to-Image (T2I) models have made remarkable progress in generating images from text prompts, but their output quality and safety still depend heavily on how prompts are phrased. Existing safety methods typically refine prompts using large language models (LLMs), but they overlook the images produced, which can result in unsafe outputs or unnecessary changes to already safe prompts. To address this, we propose an iterative prompt refinement algorithm that uses Vision Language Models (VLMs) to analyze both the input prompts and the generated images. By leveraging visual feedback, our method refines prompts more effectively, improving safety while maintaining user intent and reliability comparable to existing LLM-based approaches. Additionally, we introduce a new dataset labeled with both textual and visual safety signals using off-the-shelf multi-modal LLM, enabling supervised fine-tuning. Experimental results demonstrate that our approach produces safer outputs without compromising alignment with user intent, offering a practical solution for generating safer T2I content. Our code is available at https://github.com/ku-dmlab/IPR. \textcolor{redWARNING: This paper contains examples of harmful or inappropriate images generated by models.

The paradigm of Multimodal Large Language Models (MLLMs) offers a promising blueprint for advancing the electromagnetic (EM) domain. However, prevailing approaches often deviate from the native MLLM paradigm, instead using task-specific or pipelined architectures that lead to fundamental limitations in model performance and generalization. Fully realizing the MLLM potential in EM domain requires overcoming three main challenges: (1) Data. The scarcity of high-quality datasets with paired EM signals and descriptive text annotations used for MLLMs pre-training; (2) Benchmark. The absence of comprehensive benchmarks to systematically evaluate and compare the performance of models on EM signal-to-text tasks; (3) Model. A critical fragility in low Signal-to-Noise Ratio (SNR) environments, where critical signal features can be obscured, leading to significant performance degradation. To address these challenges, we introduce a tripartite contribution to establish a foundation for MLLMs in the EM domain. First, to overcome data scarcity, we construct and release EM-100k, a large-scale dataset comprising over 100,000 EM signal-text pairs. Second, to enable rigorous and standardized evaluation, we propose EM-Bench, the most comprehensive benchmark featuring diverse downstream tasks spanning from perception to reasoning. Finally, to tackle the core modeling challenge, we present MERLIN, a novel training framework designed not only to align low-level signal representations with high-level semantic text, but also to explicitly enhance model robustness and performance in challenging low-SNR environments. Comprehensive experiments validate our method, showing that MERLIN is state-of-the-art in the EM-Bench and exhibits remarkable robustness in low-SNR settings.

The integration of large language models (LLMs) into medical practice holds transformative potential, yet their real-world clinical utility remains limited by critical alignment challenges: (1) a disconnect between static evaluation benchmarks and dynamic clinical cognitive needs, (2) difficulties in adapting to evolving, multi-source medical standards, and (3) the inability of conventional reward models to capture nuanced, multi-dimensional medical quality criteria. To address these gaps, we propose MR-RML (Multidimensional Rubric-oriented Reward Model Learning) via GPRC (Geometric Projection Reference Constraints), a novel alignment framework that integrates medical standards into a structured "Dimensions-Scenarios-Disciplines" matrix to guide data generation and model optimization. MR-RML introduces three core innovations: (1) a "Dimensions-Scenarios-Disciplines" medical standard system that embeds domain standards into the full training pipeline; (2) an independent multi-dimensional reward model that decomposes evaluation criteria, shifting from real-time rubric-based scoring to internalized reward modeling for improved consistency and cost-efficiency; (3) geometric projection reference constraints that transform medical cognitive logic into mathematical regularization, aligning scoring gradients with clinical reasoning and enabling synthetic data-driven training. Through extensive evaluations on the authoritative medical benchmark Healthbench, our method yields substantial performance gains over the base LLM Qwen-32B (45% on the full subset and 85% on Hard subset, respectively). It achieves a SOTA among open-source LLMs with scores of 62.7 (full subset) and 44.7 (hard subset), while also outperforming the majority of closed-source models.

Multimodal large language models (MLLMs) have recently achieved remarkable progress in radiology by integrating visual perception with natural language understanding. However, they often generate clinically unsupported descriptions, known as medical hallucinations, which pose serious risks in medical applications that demand accuracy and image-grounded outputs. Through empirical analysis, we find that prompt-induced hallucinations remain prevalent in radiology MLLMs, largely due to over-sensitivity to clinical sections. To address this, we introduce Clinical Contrastive Cecoding (CCD), a training-free and retrieval-free inference framework that integrates structured clinical signals from task-specific radiology expert models. CCD introduces a dual-stage contrastive mechanism to refine token-level logits during generation, thereby enhancing clinical fidelity without modifying the base MLLM. Experiments on three datasets and multiple models demonstrate that CCD consistently improves overall performance on radiology report generation (RRG). On the MIMIC-CXR dataset, it yields up to a 17% improvement in RadGraph-F1 when applied to state-of-the-art RRG models. Our approach provides a lightweight and generalisable solution for mitigating medical hallucinations, effectively bridging expert models and MLLMs in radiology.

Deep learning (DL) has shown promise for faster, high quality accelerated MRI reconstruction. However, supervised DL methods depend on extensive amounts of fully-sampled (labeled) data and are sensitive to out-of-distribution (OOD) shifts, particularly low signal-to-noise ratio (SNR) acquisitions. To alleviate this challenge, we propose Noise2Recon, a model-agnostic, consistency training method for joint MRI reconstruction and denoising that can use both fully-sampled (labeled) and undersampled (unlabeled) scans in semi-supervised and self-supervised settings. With limited or no labeled training data, Noise2Recon outperforms compressed sensing and deep learning baselines, including supervised networks, augmentation-based training, fine-tuned denoisers, and self-supervised methods, and matches performance of supervised models, which were trained with 14x more fully-sampled scans. Noise2Recon also outperforms all baselines, including state-of-the-art fine-tuning and augmentation techniques, among low-SNR scans and when generalizing to other OOD factors, such as changes in acceleration factors and different datasets. Augmentation extent and loss weighting hyperparameters had negligible impact on Noise2Recon compared to supervised methods, which may indicate increased training stability. Our code is available at https://github.com/ad12/meddlr.

Brain MRIs are routinely acquired as multiple complementary sequences with unique contrast weighting, including T1-weighed imaging (T1w) anatomic and fluid-sensitive T2-weighted (T2w) contrasts. However, methods for learning unified representations across the multitude of MRI contrast mechanisms at health-system scale are lacking. In this study, we introduce Neuro-JEPA, a sparse multimodal neuroimaging foundation model that combines a latent predictive objective with a Mixture-of-Experts architecture to encode brain MRI across core T1w, T2w, and fluid-suppressed FLAIR imaging (FLAIR). We further provide a systematic methodological study of architectural, masking, objective, and sparsity design choices beneficial for robust neuroimaging multimodal representation learning. Neuro-JEPA was pretrained on 1,551,862 scans from 428,647 studies after modality-specific preprocessing with data curation across three core structural brain MRI sequences. We evaluated the learned representations across clinical and research settings, including 25 tasks from three health systems: NYU Langone, NYU Long Island, and Massachusetts General Hospital, and 22 tasks from 12 public datasets, covering unimodal, multimodal and cross-domain evaluation configurations. Across these benchmarks, existing neuroimaging foundation models showed inconsistent gains over a simple convolutional neural network (CNN) baseline, whereas Neuro-JEPA achieved stronger and more consistent performance across all evaluated settings. These results establish a scalable methodological framework for multimodal neuroimaging representation learning and highlight the need for foundation model evaluation protocols that include simple baselines, clinically heterogeneous cohorts and controlled multimodal comparisons.

Text-to-image (T2I) generation has achieved remarkable progress in instruction following and aesthetics. However, a persistent challenge is the prevalence of physical artifacts, such as anatomical and structural flaws, which severely degrade perceptual quality and limit application. Given the diversity and complexity of these artifacts, a systematic and fine-grained evaluation framework is required, which is lacking in current benchmarks. To fill this gap, we introduce MagicMirror, a comprehensive framework for artifacts assessment. We first establish a detailed taxonomy of generated image artifacts. Guided by this taxonomy, we manually annotate MagicData340K, the first human-annotated large-scale dataset of 340K generated images with fine-grained artifact labels. Building on this dataset, we train MagicAssessor, a Vision-Language Model (VLM) that provides detailed assessments and corresponding labels. To overcome challenges like class imbalance and reward hacking, we design a novel data sampling strategy and a multi-level reward system for Group Relative Policy Optimization (GRPO). Finally, we leverage MagicAssessor to construct MagicBench, an automated benchmark for evaluating the image artifacts of current T2I models. Our evaluation with MagicBench reveals that despite their widespread adoption, even top-tier models like GPT-image-1 are consistently plagued by significant artifacts, highlighting artifact reduction as a critical frontier for future T2I development. Project page: https://wj-inf.github.io/MagicMirror-page/.

Multimodal large language models (MLLMs) have advanced clinical tasks for common conditions, but their performance on rare diseases remains largely untested. In rare-disease scenarios, clinicians often lack prior clinical knowledge, forcing them to rely strictly on case-level evidence for clinical judgments. Existing benchmarks predominantly evaluate common-condition, single-image settings, leaving multimodal and multi-image evidence integration under rare-disease data scarcity systematically unevaluated. We introduce MMRareBench, to our knowledge the first rare-disease benchmark jointly evaluating multimodal and multi-image clinical capability across four workflow-aligned tracks: diagnosis, treatment planning, cross-image evidence alignment, and examination suggestion. The benchmark comprises 1,756 question-answer pairs with 7,958 associated medical images curated from PMC case reports, with Orphanet-anchored ontology alignment, track-specific leakage control, evidence-grounded annotations, and a two-level evaluation protocol. A systematic evaluation of 23 MLLMs reveals fragmented capability profiles and universally low treatment-planning performance, with medical-domain models trailing general-purpose MLLMs substantially on multi-image tracks despite competitive diagnostic scores. These patterns are consistent with a capacity dilution effect: medical fine-tuning can narrow the diagnostic gap but may erode the compositional multi-image capability that rare-disease evidence integration demands.

Large Reasoning Models (LRMs) have introduced a new paradigm in AI by enabling models to ``think before responding" via chain-of-thought reasoning. However, the absence of open and reproducible recipes for building reasoning-centric medical LMMs hinders community-wide research, analysis, and comparison. In this paper, we present MedVLThinker, a suite of simple yet strong baselines. Our fully open recipe consists of: (1) systematic data curation for both text-only and image-text medical data, filtered according to varying levels of reasoning difficulty, and (2) two training paradigms: Supervised Fine-Tuning (SFT) on distilled reasoning traces and Reinforcement Learning with Verifiable Rewards (RLVR) based on final answer correctness. Across extensive experiments on the Qwen2.5-VL model family (3B, 7B) and six medical QA benchmarks, we find that RLVR consistently and significantly outperforms SFT. Additionally, under the RLVR framework, a key, counter-intuitive finding is that training on our curated text-only reasoning data provides a more substantial performance boost than training on multimodal image-text data. Our best open 7B model, trained using the RLVR recipe on text-only data, establishes a new state-of-the-art on existing public VQA benchmarks, surpassing all previous open-source medical LMMs. Furthermore, scaling our model to 32B achieves performance on par with the proprietary GPT-4o. We release all curated data, models, and code to provide the community with a strong, open foundation for future research in multimodal medical reasoning.

Modern smartphone camera quality heavily relies on the image signal processor (ISP) to enhance captured raw images, utilizing carefully designed modules to produce final output images encoded in a standard color space (e.g., sRGB). Neural-based end-to-end learnable ISPs offer promising advancements, potentially replacing traditional ISPs with their ability to adapt without requiring extensive tuning for each new camera model, as is often the case for nearly every module in traditional ISPs. However, the key challenge with the recent learning-based ISPs is the urge to collect large paired datasets for each distinct camera model due to the influence of intrinsic camera characteristics on the formation of input raw images. This paper tackles this challenge by introducing a novel method for unpaired learning of raw-to-raw translation across diverse cameras. Specifically, we propose Rawformer, an unsupervised Transformer-based encoder-decoder method for raw-to-raw translation. It accurately maps raw images captured by a certain camera to the target camera, facilitating the generalization of learnable ISPs to new unseen cameras. Our method demonstrates superior performance on real camera datasets, achieving higher accuracy compared to previous state-of-the-art techniques, and preserving a more robust correlation between the original and translated raw images. The codes and the pretrained models are available at https://github.com/gosha20777/rawformer.

While recent text-to-image (T2I) models show impressive capabilities in synthesizing images from brief descriptions, their performance significantly degrades when confronted with long, detail-intensive prompts required in professional applications. We present DetailMaster, the first comprehensive benchmark specifically designed to evaluate T2I models' systematical abilities to handle extended textual inputs that contain complex compositional requirements. Our benchmark introduces four critical evaluation dimensions: Character Attributes, Structured Character Locations, Multi-Dimensional Scene Attributes, and Explicit Spatial/Interactive Relationships. The benchmark comprises long and detail-rich prompts averaging 284.89 tokens, with high quality validated by expert annotators. Evaluation on 7 general-purpose and 5 long-prompt-optimized T2I models reveals critical performance limitations: state-of-the-art models achieve merely ~50% accuracy in key dimensions like attribute binding and spatial reasoning, while all models showing progressive performance degradation as prompt length increases. Our analysis highlights systemic failures in structural comprehension and detail overload handling, motivating future research into architectures with enhanced compositional reasoning. We open-source the dataset, data curation code, and evaluation tools to advance detail-rich T2I generation and enable broad applications that would otherwise be infeasible due to the lack of a dedicated benchmark.

Despite recent progress, vision-language encoders struggle with two core limitations: (1) weak alignment between language and dense vision features, which hurts tasks like open-vocabulary semantic segmentation; and (2) high token counts for fine-grained visual representations, which limits scalability to long videos. This work addresses both limitations. We propose T-REN (Text-aligned Region Encoder Network), an efficient encoder that maps visual data to a compact set of text-aligned region-level representations (or region tokens). T-REN achieves this through a lightweight network added on top of a frozen vision backbone, trained to pool patch-level representations within each semantic region into region tokens and align them with region-level text annotations. With only 3.7% additional parameters compared to the vision-language backbone, this design yields substantially stronger dense cross-modal understanding while reducing the token count by orders of magnitude. Specifically, T-REN delivers +5.9 mIoU on ADE20K open-vocabulary segmentation, +18.4% recall on COCO object-level text-image retrieval, +15.6% recall on Ego4D video object localization, and +17.6% mIoU on VSPW video scene parsing, all while reducing token counts by more than 24x for images and 187x for videos compared to the patch-based vision-language backbone. The code and model are available at https://github.com/savya08/T-REN.

In this work, we address the TrackRAD2025 challenge of real-time tumor tracking in cine-MRI sequences of the thoracic and abdominal regions under strong data scarcity constraints. Two complementary strategies were explored: (i) unsupervised registration with the IMPACT similarity metric and (ii) foundation model-based segmentation leveraging SAM 2.1 and its recent variants through prompt-based interaction. Due to the one-second runtime constraint, the SAM-based method was ultimately selected. The final configuration used SAM2.1 b+ with mask-based prompts from the first annotated slice, fine-tuned solely on the small labeled subset from TrackRAD2025. Training was configured to minimize overfitting, using 1024x1024 patches (batch size 1), standard augmentations, and a balanced Dice + IoU loss. A low uniform learning rate (0.0001) was applied to all modules (prompt encoder, decoder, Hiera backbone) to preserve generalization while adapting to annotator-specific styles. Training lasted 300 epochs (~12h on RTX A6000, 48GB). The same inference strategy was consistently applied across all anatomical sites and MRI field strengths. Test-time augmentation was considered but ultimately discarded due to negligible performance gains. The final model was selected based on the highest Dice Similarity Coefficient achieved on the validation set after fine-tuning. On the hidden test set, the model reached a Dice score of 0.8794, ranking 6th overall in the TrackRAD2025 challenge. These results highlight the strong potential of foundation models for accurate and real-time tumor tracking in MRI-guided radiotherapy.

Despite the success of large language models (LLMs) in various domains, their potential in Traditional Chinese Medicine (TCM) remains largely underexplored due to two critical barriers: (1) the scarcity of high-quality TCM data and (2) the inherently multimodal nature of TCM diagnostics, which involve looking, listening, smelling, and pulse-taking. These sensory-rich modalities are beyond the scope of conventional LLMs. To address these challenges, we present ShizhenGPT, the first multimodal LLM tailored for TCM. To overcome data scarcity, we curate the largest TCM dataset to date, comprising 100GB+ of text and 200GB+ of multimodal data, including 1.2M images, 200 hours of audio, and physiological signals. ShizhenGPT is pretrained and instruction-tuned to achieve deep TCM knowledge and multimodal reasoning. For evaluation, we collect recent national TCM qualification exams and build a visual benchmark for Medicinal Recognition and Visual Diagnosis. Experiments demonstrate that ShizhenGPT outperforms comparable-scale LLMs and competes with larger proprietary models. Moreover, it leads in TCM visual understanding among existing multimodal LLMs and demonstrates unified perception across modalities like sound, pulse, smell, and vision, paving the way toward holistic multimodal perception and diagnosis in TCM. Datasets, models, and code are publicly available. We hope this work will inspire further exploration in this field.

In recent years, Text-to-Image (T2I) models have been extensively studied, especially with the emergence of diffusion models that achieve state-of-the-art results on T2I synthesis tasks. However, existing benchmarks heavily rely on subjective human evaluation, limiting their ability to holistically assess the model's capabilities. Furthermore, there is a significant gap between efforts in developing new T2I architectures and those in evaluation. To address this, we introduce HRS-Bench, a concrete evaluation benchmark for T2I models that is Holistic, Reliable, and Scalable. Unlike existing bench-marks that focus on limited aspects, HRS-Bench measures 13 skills that can be categorized into five major categories: accuracy, robustness, generalization, fairness, and bias. In addition, HRS-Bench covers 50 scenarios, including fashion, animals, transportation, food, and clothes. We evaluate nine recent large-scale T2I models using metrics that cover a wide range of skills. A human evaluation aligned with 95% of our evaluations on average was conducted to probe the effectiveness of HRS-Bench. Our experiments demonstrate that existing models often struggle to generate images with the desired count of objects, visual text, or grounded emotions. We hope that our benchmark help ease future text-to-image generation research. The code and data are available at https://eslambakr.github.io/hrsbench.github.io

Medical Vision-Language Models (MVLMs) have achieved par excellence generalization in medical image analysis, yet their performance under noisy, corrupted conditions remains largely untested. Clinical imaging is inherently susceptible to acquisition artifacts and noise; however, existing evaluations predominantly assess generally clean datasets, overlooking robustness -- i.e., the model's ability to perform under real-world distortions. To address this gap, we first introduce MediMeta-C, a corruption benchmark that systematically applies several perturbations across multiple medical imaging datasets. Combined with MedMNIST-C, this establishes a comprehensive robustness evaluation framework for MVLMs. We further propose RobustMedCLIP, a visual encoder adaptation of a pretrained MVLM that incorporates few-shot tuning to enhance resilience against corruptions. Through extensive experiments, we benchmark 5 major MVLMs across 5 medical imaging modalities, revealing that existing models exhibit severe degradation under corruption and struggle with domain-modality tradeoffs. Our findings highlight the necessity of diverse training and robust adaptation strategies, demonstrating that efficient low-rank adaptation when paired with few-shot tuning, improves robustness while preserving generalization across modalities.

One of the key shortcomings in current text-to-image (T2I) models is their inability to consistently generate images which faithfully follow the spatial relationships specified in the text prompt. In this paper, we offer a comprehensive investigation of this limitation, while also developing datasets and methods that achieve state-of-the-art performance. First, we find that current vision-language datasets do not represent spatial relationships well enough; to alleviate this bottleneck, we create SPRIGHT, the first spatially-focused, large scale dataset, by re-captioning 6 million images from 4 widely used vision datasets. Through a 3-fold evaluation and analysis pipeline, we find that SPRIGHT largely improves upon existing datasets in capturing spatial relationships. To demonstrate its efficacy, we leverage only ~0.25% of SPRIGHT and achieve a 22% improvement in generating spatially accurate images while also improving the FID and CMMD scores. Secondly, we find that training on images containing a large number of objects results in substantial improvements in spatial consistency. Notably, we attain state-of-the-art on T2I-CompBench with a spatial score of 0.2133, by fine-tuning on <500 images. Finally, through a set of controlled experiments and ablations, we document multiple findings that we believe will enhance the understanding of factors that affect spatial consistency in text-to-image models. We publicly release our dataset and model to foster further research in this area.

Purpose: In radiology, large language models (LLMs), including ChatGPT, have recently gained attention, and their utility is being rapidly evaluated. However, concerns have emerged regarding their reliability in clinical applications due to limitations such as hallucinations and insufficient referencing. To address these issues, we focus on the latest technology, retrieval-augmented generation (RAG), which enables LLMs to reference reliable external knowledge (REK). Specifically, this study examines the utility and reliability of a recently released RAG-equipped LLM (RAG-LLM), NotebookLM, for staging lung cancer. Materials and methods: We summarized the current lung cancer staging guideline in Japan and provided this as REK to NotebookLM. We then tasked NotebookLM with staging 100 fictional lung cancer cases based on CT findings and evaluated its accuracy. For comparison, we performed the same task using a gold-standard LLM, GPT-4 Omni (GPT-4o), both with and without the REK. Results: NotebookLM achieved 86% diagnostic accuracy in the lung cancer staging experiment, outperforming GPT-4o, which recorded 39% accuracy with the REK and 25% without it. Moreover, NotebookLM demonstrated 95% accuracy in searching reference locations within the REK. Conclusion: NotebookLM successfully performed lung cancer staging by utilizing the REK, demonstrating superior performance compared to GPT-4o. Additionally, it provided highly accurate reference locations within the REK, allowing radiologists to efficiently evaluate the reliability of NotebookLM's responses and detect possible hallucinations. Overall, this study highlights the potential of NotebookLM, a RAG-LLM, in image diagnosis.

Text-to-Image (T2I) models are capable of generating high-quality artistic creations and visual content. However, existing research and evaluation standards predominantly focus on image realism and shallow text-image alignment, lacking a comprehensive assessment of complex semantic understanding and world knowledge integration in text to image generation. To address this challenge, we propose WISE, the first benchmark specifically designed for World Knowledge-Informed Semantic Evaluation. WISE moves beyond simple word-pixel mapping by challenging models with 1000 meticulously crafted prompts across 25 sub-domains in cultural common sense, spatio-temporal reasoning, and natural science. To overcome the limitations of traditional CLIP metric, we introduce WiScore, a novel quantitative metric for assessing knowledge-image alignment. Through comprehensive testing of 20 models (10 dedicated T2I models and 10 unified multimodal models) using 1,000 structured prompts spanning 25 subdomains, our findings reveal significant limitations in their ability to effectively integrate and apply world knowledge during image generation, highlighting critical pathways for enhancing knowledge incorporation and application in next-generation T2I models. Code and data are available at https://github.com/PKU-YuanGroup/WISE.

Radiology report generation (RRG) is commonly formulated as a single-path generation task, where a multimodal large language model (MLLM) produces one decoded report as the final output. While recent progress has largely been driven by scaling training data, model capacity, and retrieval mechanisms, improving report quality at inference time remains underexplored. In this work, we observe that fixed radiology MLLMs often generate clinically stronger reports elsewhere in their candidate pool than the one selected by default decoding, suggesting that inference-time decision making remains an overlooked bottleneck. To address this, we propose Clinical Consensus Selection (CCS), a decoder-agnostic inference-time selection framework that samples multiple candidate reports and selects the one with the highest clinical consensus across the rollout pool. CCS unifies text-based utilities with a radiology-adapted utility computed by an image--report-trained multimodal embedder, which measures candidate agreement beyond surface-level textual similarity. Across three datasets and multiple radiology MLLMs, CCS consistently improves inference-time performance over single-path decoding and generic Best-of-N baselines, with particularly clear gains on clinical metrics. Further analysis shows that image-grounded utility forms a selection axis distinct from textual consensus and that substantial headroom remains for improving RRG at inference time.

In recent years, there has been a growing trend in computer vision towards exploiting RAW sensor data, which preserves richer information compared to conventional low-bit RGB images. Early studies mainly focused on enhancing visual quality, while more recent efforts aim to leverage the abundant information in RAW data to improve the performance of visual perception tasks such as object detection and segmentation. However, existing approaches still face two key limitations: large-scale ISP networks impose heavy computational overhead, while methods based on tuning traditional ISP pipelines are restricted by limited representational capacity.To address these issues, we propose Task-Aware Image Signal Processing (TA-ISP), a compact RAW-to-RGB framework that produces task-oriented representations for pretrained vision models. Instead of heavy dense convolutional pipelines, TA-ISP predicts a small set of lightweight, multi-scale modulation operators that act at global, regional, and pixel scales to reshape image statistics across different spatial extents. This factorized control significantly expands the range of spatially varying transforms that can be represented while keeping memory usage, computation, and latency tightly constrained. Evaluated on several RAW-domain detection and segmentation benchmarks under both daytime and nighttime conditions, TA-ISP consistently improves downstream accuracy while markedly reducing parameter count and inference time, making it well suited for deployment on resource-constrained devices.

With the increasing use of RetrievalAugmented Generation (RAG), strong retrieval models have become more important than ever. In healthcare, multimodal retrieval models that combine information from both text and images offer major advantages for many downstream tasks such as question answering, cross-modal retrieval, and multimodal summarization, since medical data often includes both formats. However, there is currently no standard benchmark to evaluate how well these models perform in medical settings. To address this gap, we introduce M3Retrieve, a Multimodal Medical Retrieval Benchmark. M3Retrieve, spans 5 domains,16 medical fields, and 4 distinct tasks, with over 1.2 Million text documents and 164K multimodal queries, all collected under approved licenses. We evaluate leading multimodal retrieval models on this benchmark to explore the challenges specific to different medical specialities and to understand their impact on retrieval performance. By releasing M3Retrieve, we aim to enable systematic evaluation, foster model innovation, and accelerate research toward building more capable and reliable multimodal retrieval systems for medical applications. The dataset and the baselines code are available in this github page https://github.com/AkashGhosh/M3Retrieve.

Objective: To determine if a realistic, but computationally efficient model of the electrocardiogram can be used to pre-train a deep neural network (DNN) with a wide range of morphologies and abnormalities specific to a given condition - T-wave Alternans (TWA) as a result of Post-Traumatic Stress Disorder, or PTSD - and significantly boost performance on a small database of rare individuals. Approach: Using a previously validated artificial ECG model, we generated 180,000 artificial ECGs with or without significant TWA, with varying heart rate, breathing rate, TWA amplitude, and ECG morphology. A DNN, trained on over 70,000 patients to classify 25 different rhythms, was modified the output layer to a binary class (TWA or no-TWA, or equivalently, PTSD or no-PTSD), and transfer learning was performed on the artificial ECG. In a final transfer learning step, the DNN was trained and cross-validated on ECG from 12 PTSD and 24 controls for all combinations of using the three databases. Main results: The best performing approach (AUROC = 0.77, Accuracy = 0.72, F1-score = 0.64) was found by performing both transfer learning steps, using the pre-trained arrhythmia DNN, the artificial data and the real PTSD-related ECG data. Removing the artificial data from training led to the largest drop in performance. Removing the arrhythmia data from training provided a modest, but significant, drop in performance. The final model showed no significant drop in performance on the artificial data, indicating no overfitting. Significance: In healthcare, it is common to only have a small collection of high-quality data and labels, or a larger database with much lower quality (and less relevant) labels. The paradigm presented here, involving model-based performance boosting, provides a solution through transfer learning on a large realistic artificial database, and a partially relevant real database.

Automated radiology report generation (RRG) aims to produce detailed textual reports from clinical imaging, such as computed tomography (CT) scans, to improve the accuracy and efficiency of diagnosis and provision of management advice. RRG is complicated by two key challenges: (1) inherent complexity in extracting relevant information from imaging data under resource constraints, and (2) difficulty in objectively evaluating discrepancies between model-generated and expert-written reports. To address these challenges, we propose mu^2LLM, a textbf{mu}ltiscale textbf{mu}ltimodal large language models for RRG tasks. The novel {mu}^2Tokenizer, as an intermediate layer, integrates multi-modal features from the multiscale visual tokenizer and the text tokenizer, then enhances report generation quality through direct preference optimization (DPO), guided by GREEN-RedLlama. Experimental results on four large CT image-report medical datasetdemonstrate that our method outperforms existing approaches, highlighting the potential of our fine-tuned mu^2LLMs on limited data for RRG tasks.

Resection and whole brain radiotherapy (WBRT) are the standards of care for the treatment of patients with brain metastases (BM) but are often associated with cognitive side effects. Stereotactic radiosurgery (SRS) involves a more targeted treatment approach and has been shown to avoid the side effects associated with WBRT. However, SRS requires precise identification and delineation of BM. While many AI algorithms have been developed for this purpose, their clinical adoption has been limited due to poor model performance in the clinical setting. Major reasons for non-generalizable algorithms are the limitations in the datasets used for training the AI network. The purpose of this study was to create a large, heterogenous, annotated BM dataset for training and validation of AI models to improve generalizability. We present a BM dataset of 200 patients with pretreatment T1, T1 post-contrast, T2, and FLAIR MR images. The dataset includes contrast-enhancing and necrotic 3D segmentations on T1 post-contrast and whole tumor (including peritumoral edema) 3D segmentations on FLAIR. Our dataset contains 975 contrast-enhancing lesions, many of which are sub centimeter, along with clinical and imaging feature information. We used a streamlined approach to database-building leveraging a PACS-integrated segmentation workflow.

Radiology reports are critical for clinical decision-making but often lack a standardized format, limiting both human interpretability and machine learning (ML) applications. While large language models (LLMs) have shown strong capabilities in reformatting clinical text, their high computational requirements, lack of transparency, and data privacy concerns hinder practical deployment. To address these challenges, we explore lightweight encoder-decoder models (<300M parameters)-specifically T5 and BERT2BERT-for structuring radiology reports from the MIMIC-CXR and CheXpert Plus datasets. We benchmark these models against eight open-source LLMs (1B-70B), adapted using prefix prompting, in-context learning (ICL), and low-rank adaptation (LoRA) finetuning. Our best-performing lightweight model outperforms all LLMs adapted using prompt-based techniques on a human-annotated test set. While some LoRA-finetuned LLMs achieve modest gains over the lightweight model on the Findings section (BLEU 6.4%, ROUGE-L 4.8%, BERTScore 3.6%, F1-RadGraph 1.1%, GREEN 3.6%, and F1-SRR-BERT 4.3%), these improvements come at the cost of substantially greater computational resources. For example, LLaMA-3-70B incurred more than 400 times the inference time, cost, and carbon emissions compared to the lightweight model. These results underscore the potential of lightweight, task-specific models as sustainable and privacy-preserving solutions for structuring clinical text in resource-constrained healthcare settings.

MLLMs MLLMs are beginning to appear in clinical workflows, but their ability to perform complex medical reasoning remains unclear. We present Med-CMR, a fine-grained Medical Complex Multimodal Reasoning benchmark. Med-CMR distinguishes from existing counterparts by three core features: 1) Systematic capability decomposition, splitting medical multimodal reasoning into fine-grained visual understanding and multi-step reasoning to enable targeted evaluation; 2) Challenging task design, with visual understanding across three key dimensions (small-object detection, fine-detail discrimination, spatial understanding) and reasoning covering four clinically relevant scenarios (temporal prediction, causal reasoning, long-tail generalization, multi-source integration); 3) Broad, high-quality data coverage, comprising 20,653 Visual Question Answering (VQA) pairs spanning 11 organ systems and 12 imaging modalities, validated via a rigorous two-stage (human expert + model-assisted) review to ensure clinical authenticity. We evaluate 18 state-of-the-art MLLMs with Med-CMR, revealing GPT-5 as the top-performing commercial model: 57.81 accuracy on multiple-choice questions (MCQs) and a 48.70 open-ended score, outperforming Gemini 2.5 Pro (49.87 MCQ accuracy, 45.98 open-ended score) and leading open-source model Qwen3-VL-235B-A22B (49.34 MCQ accuracy, 42.62 open-ended score). However, specialized medical MLLMs do not reliably outperform strong general models, and long-tail generalization emerges as the dominant failure mode. Med-CMR thus provides a stress test for visual-reasoning integration and rare-case robustness in medical MLLMs, and a rigorous yardstick for future clinical systems.

Text-to-Image Retrieval (T2IR) is a highly valuable task that aims to match a given textual query to images in a gallery. Existing benchmarks primarily focus on textual queries describing overall image semantics or foreground salient objects, possibly overlooking inconspicuous small objects, especially in complex environments. Such small object retrieval is crucial, as in real-world applications, the targets of interest are not always prominent in the image. Thus, we introduce SORCE (Small Object Retrieval in Complex Environments), a new subfield of T2IR, focusing on retrieving small objects in complex images with textual queries. We propose a new benchmark, SORCE-1K, consisting of images with complex environments and textual queries describing less conspicuous small objects with minimal contextual cues from other salient objects. Preliminary analysis on SORCE-1K finds that existing T2IR methods struggle to capture small objects and encode all the semantics into a single embedding, leading to poor retrieval performance on SORCE-1K. Therefore, we propose to represent each image with multiple distinctive embeddings. We leverage Multimodal Large Language Models (MLLMs) to extract multiple embeddings for each image instructed by a set of Regional Prompts (ReP). Experimental results show that our multi-embedding approach through MLLM and ReP significantly outperforms existing T2IR methods on SORCE-1K. Our experiments validate the effectiveness of SORCE-1K for benchmarking SORCE performances, highlighting the potential of multi-embedding representation and text-customized MLLM features for addressing this task.

Recently, large-scale text-to-image (T2I) models have shown impressive performance in generating high-fidelity images, but with limited controllability, e.g., precisely specifying the content in a specific region with a free-form text description. In this paper, we propose an effective technique for such regional control in T2I generation. We augment T2I models' inputs with an extra set of position tokens, which represent the quantized spatial coordinates. Each region is specified by four position tokens to represent the top-left and bottom-right corners, followed by an open-ended natural language regional description. Then, we fine-tune a pre-trained T2I model with such new input interface. Our model, dubbed as ReCo (Region-Controlled T2I), enables the region control for arbitrary objects described by open-ended regional texts rather than by object labels from a constrained category set. Empirically, ReCo achieves better image quality than the T2I model strengthened by positional words (FID: 8.82->7.36, SceneFID: 15.54->6.51 on COCO), together with objects being more accurately placed, amounting to a 20.40% region classification accuracy improvement on COCO. Furthermore, we demonstrate that ReCo can better control the object count, spatial relationship, and region attributes such as color/size, with the free-form regional description. Human evaluation on PaintSkill shows that ReCo is +19.28% and +17.21% more accurate in generating images with correct object count and spatial relationship than the T2I model.

Scene text recognition (STR) enables computers to read text in natural scenes such as object labels, road signs and instructions. STR helps machines perform informed decisions such as what object to pick, which direction to go, and what is the next step of action. In the body of work on STR, the focus has always been on recognition accuracy. There is little emphasis placed on speed and computational efficiency which are equally important especially for energy-constrained mobile machines. In this paper we propose ViTSTR, an STR with a simple single stage model architecture built on a compute and parameter efficient vision transformer (ViT). On a comparable strong baseline method such as TRBA with accuracy of 84.3%, our small ViTSTR achieves a competitive accuracy of 82.6% (84.2% with data augmentation) at 2.4x speed up, using only 43.4% of the number of parameters and 42.2% FLOPS. The tiny version of ViTSTR achieves 80.3% accuracy (82.1% with data augmentation), at 2.5x the speed, requiring only 10.9% of the number of parameters and 11.9% FLOPS. With data augmentation, our base ViTSTR outperforms TRBA at 85.2% accuracy (83.7% without augmentation) at 2.3x the speed but requires 73.2% more parameters and 61.5% more FLOPS. In terms of trade-offs, nearly all ViTSTR configurations are at or near the frontiers to maximize accuracy, speed and computational efficiency all at the same time.

Most medical multimodal benchmarks focus on static tasks such as image question answering, report generation, and plain-language rewriting. Patient education is more demanding: systems must identify relevant evidence across images, show patients where to look, explain findings in accessible language, and handle confusion or distress. Yet most patient education work remains text-only, even though combined image-and-text explanations may better support understanding. We introduce MedImageEdu, a benchmark for multi-turn, evidence-grounded radiology patient education. Each case provides a radiology report with report text and case images. A DoctorAgent interacts with a PatientAgent, conditioned on a hidden profile that captures factors such as education level, health literacy, and personality. When a patient question would benefit from visual support, the DoctorAgent can issue drawing instructions grounded in the report, case images, and the current question to a benchmark-provided drawing tool. The tool returns image(s), after which the DoctorAgent produces a final multimodal response consisting of the image(s) and a grounded plain-language explanation. MedImageEdu contains 150 cases from three sources and evaluates both the consultation process and the final multimodal response along five dimensions: Consultation, Safety and Scope, Language Quality, Drawing Quality, and Image-Text Response Quality. Across representative open- and closed-source vision-language model agents, we find three consistent gaps: fluent language often outpaces faithful visual grounding, safety is the weakest dimension across disease categories, and emotionally tense interactions are harder than low education or low health literacy. MedImageEdu provides a controlled testbed for assessing whether multimodal agents can teach from evidence rather than merely answer from text.

Both zero-shot and tuning-based customized text-to-image (CT2I) generation have made significant progress for storytelling content creation. In contrast, research on customized text-to-video (CT2V) generation remains relatively limited. Existing zero-shot CT2V methods suffer from poor generalization, while another line of work directly combining tuning-based T2I models with temporal motion modules often leads to the loss of structural and texture information. To bridge this gap, we propose an autoregressive structure and texture propagation module (STPM), which extracts key structural and texture features from the reference subject and injects them autoregressively into each video frame to enhance consistency. Additionally, we introduce a test-time reward optimization (TTRO) method to further refine fine-grained details. Quantitative and qualitative experiments validate the effectiveness of STPM and TTRO, demonstrating improvements of 7.8 and 13.1 in CLIP-I and DINO consistency metrics over the baseline, respectively.

Text-to-image (T2I) models have shown remarkable progress, but their potential to generate harmful content remains a critical concern in the ML community. While various safety mechanisms have been developed, the field lacks systematic tools for evaluating their effectiveness against real-world misuse scenarios. In this work, we propose ICER, a novel red-teaming framework that leverages Large Language Models (LLMs) and a bandit optimization-based algorithm to generate interpretable and semantic meaningful problematic prompts by learning from past successful red-teaming attempts. Our ICER efficiently probes safety mechanisms across different T2I models without requiring internal access or additional training, making it broadly applicable to deployed systems. Through extensive experiments, we demonstrate that ICER significantly outperforms existing prompt attack methods in identifying model vulnerabilities while maintaining high semantic similarity with intended content. By uncovering that successful jailbreaking instances can systematically facilitate the discovery of new vulnerabilities, our work provides crucial insights for developing more robust safety mechanisms in T2I systems.